{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:24:12Z","timestamp":1788355452267,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI19C0481"],"award-info":[{"award-number":["HI19C0481"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HC19C0077"],"award-info":[{"award-number":["HC19C0077"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Association between protonpump inhibitors (PPIs) and osteoporosis, hip fractures has not been fully elucidated. We aimed to evaluate the relationship between PPIs use and the risk of osteoporosis and hip fractures in the databases converted to a common data model (CDM) and to compare the results across the databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a population\u2010based, propensity\u2010matched, retrospective cohort study that included patients aged\u00a0\u2265\u00a050\u00a0years who were prescribed with PPIs for over 180\u00a0days. We compared the incidence of osteoporosis and hip fractures between new PPI user and new user of other drugs using the Cox proportional hazards model and performed meta\u2010analysis in the electronic health record (EHR) databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the Korean National Health Insurance Service (NHIS)\u2013CDM database, long\u2010term PPI users had greater risk of osteoporosis [PPIs <jats:italic>vs<\/jats:italic> non\u2010PPIs groups, 28.42\/1000 person\u2010years <jats:italic>vs<\/jats:italic> 19.29\/1000 person\u2010years; hazard ratio (HR), 1.62; 95% confidence interval (CI), 1.22\u20132.15; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001]. The meta\u2010analytic results of six EHR databases also showed similar result (pooled HR, 1.57; 95% CI, 1.28\u20131.92). In the analysis of hip fracture, PPI use was not significantly associated with a hip fracture in the NHIS\u2013CDM database (PPI <jats:italic>vs<\/jats:italic> non\u2010PPI groups, 3.09\/1000 person\u2010years <jats:italic>vs<\/jats:italic> 2.26\/1000 person\u2010years; HR, 1.45; 95% CI, 0.74\u20132.80; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.27). However, in the meta\u2010analysis of four EHR databases, the risk of hip fractures was higher in PPI users (pooled HR, 1.82; 95% CI, 1.04\u20133.19).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term PPI was significantly associated with osteoporosis; however, the results of hip fractures were inconsistent. Further study based on better data quality may be needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15879","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T02:39:57Z","timestamp":1651545597000},"page":"1534-1543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Long\u2010term proton pump inhibitor use and risk of osteoporosis and hip fractures: A nationwide population\u2010based and multicenter cohort study using a common data model"],"prefix":"10.1111","volume":"37","author":[{"given":"Da Hee","family":"Park","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kangdong Sacred Heart Hospital, Hallym University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-0135","authenticated-orcid":false,"given":"Seung 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