{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:32:24Z","timestamp":1790818344147,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Thiopurines are widely used to maintain remission in both ulcerative colitis (UC) and Crohn's disease (CD). Reported effectiveness and tolerability rates have been variable across studies. There are only sparse data in Asian population regarding the long\u2010term efficacy and safety of thiopurines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Records of 5351 patients followed up at inflammatory bowel disease (IBD) clinic, All India Institute of Medical Sciences, New Delhi from 2004 to 2020 were evaluated retrospectively. Safety was evaluated in terms of long\u2010term adverse events and development of malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 5351 patients with IBD, 1093 who received thiopurine for &gt;\u00a03\u00a0months (UC\u00a0=\u00a0788 [proctitis\u20141.9%, left\u2010sided colitis\u201444.9%, &amp; pancolitis\u201453.1%] &amp; CD\u00a0=\u00a0305 [inflammatory\u201442.6%, stricturing\u201446.9%, &amp; fistulizing\u201410.5%]) were included (60.8%\u2014male patients). Follow up and treatment duration on thiopurine were 7 (4\u201312) years and 39.4\u00a0\u00b1\u00a040.3\u00a0months, respectively, with 254 (23.2%) patients receiving thiopurines for more than 5 and 68 (6.2%) receiving for more than 10\u00a0years. Three hundred and fifty\u2010nine (UC: 249 [31.6%]; CD: 110 [36.1%]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.1) patients developed adverse events; commonest was myelosuppression (23.4%) followed by gastrointestinal intolerance (3%), flu\u2010like illness (1.7%), and arthralgia\/myalgia (1.4%). Myelosuppression was the commonest cause of thiopurine withdrawal. No patient (including 254 patients on thiopurine for \u2265\u00a05\u00a0years) developed lymphoma or non\u2010melanoma skin cancer. The cumulative probability of staying free from adverse events in overall IBD cohort at 1, 2, and 5\u00a0years was 78.6%, 71.9%, and 68.4%, respectively, and this was comparable between UC and CD (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.09).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010term follow up of patients with IBD from northern India on thiopurine monotherapy demonstrated minimal risk of development of lymphoma as well as non\u2010melanoma skin cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15880","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T02:03:47Z","timestamp":1651543427000},"page":"1544-1553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Minimal risk of lymphoma and non\u2010melanoma skin cancer despite long\u2010term use of thiopurines in patients with inflammatory bowel disease: A longitudinal cohort analysis from northern India"],"prefix":"10.1111","volume":"37","author":[{"given":"Mukesh Kumar","family":"Ranjan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Human Nutrition All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Kante","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Human Nutrition All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudheer Kumar","family":"Vuyyuru","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Human Nutrition All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peeyush","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Human Nutrition All India Institute of Medical Sciences  New Delhi 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