{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T20:51:05Z","timestamp":1772052665485,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>There remains lots of unknowns for small intestinal mucosal breaks (SIMBs). The application of magnetic controlled capsule endoscope (MCCE) may provide a better understanding of SIMBs. The aim of our study was to investigate the prevalence and characteristics of SIMBs in the general population as well as risk factors for SIMBs other than aspirin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data on individuals who visited our institute between January 2019 and February 2021 for MCCE examination as a health check were collected and analyzed retrospectively. All study participants must have completed the small bowel inspection. Multivariate analysis was employed to reveal the independent risk factors for SIMBs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1599 participants, 103 of whom were aspirin users, were finally included. The prevalence of SIMBs was 8.3% (132\/1599) in all participants, with 36.9% (38\/103) in aspirin users and 6.3% (94\/1496) in non\u2010aspirin users. The multivariate analysis showed that in addition to aspirin (OR: 6.17, 95% CI: 3.25\u201311.58), obesity (OR: 2.30, 95% CI: 1.38\u20133.92) and smoking (OR: 1.85, 95% CI: 1.56\u20133.20) were also independent risk factors for SIMBs. Jejunum involvement was more common in aspirin users (20\/38, 52.6%), while ilium involvement was more common in non\u2010aspirin users (58\/94, 61.7%). Moderate SIMBs (erosions) were more common in aspirin users (17\/38, 44.7%), while severe SIMBs (large erosions\/ulcers) were more common in non\u2010aspirin users (17\/94, 18.1%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risk factors for SIMBs include aspirin as well as smoking and obesity, and the severity and distributive features of SIMBs differ between aspirin users and non\u2010aspirin users.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15892","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T05:44:10Z","timestamp":1654062250000},"page":"1596-1602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk factors for small\u2010intestinal mucosal breaks beyond aspirin"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9500-7288","authenticated-orcid":false,"given":"Xi","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The Second Medical Center and National Clinical Research Center for Geriatric Diseases Chinese PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Health Management Institution, The Second Medical Center and National Clinical Research Center for Geriatric Diseases Chinese PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The Second Medical Center and National Clinical Research Center for Geriatric Diseases Chinese PLA General Hospital  Beijing 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