{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:48:53Z","timestamp":1787068133817,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000531"],"award-info":[{"award-number":["82000531"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>The efficacy and safety of amoxicillin\u2010vonoprazan (VA) dual therapy remained unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This systematic review was conducted in accordance with the PRISMA 2009 guidelines. A systematic search of the Pubmed, Embase, and Cochrane database was conducted using the combination of \u201c\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      or\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      or\n                      <jats:italic>Hp<\/jats:italic>\n                      ,\u201d \u201camoxicillin or\u00a0penicillin,\u201d and \u201cVonoprazan or TAK\u2010438 or Takecab or (potassium AND competitive) or potassium\u2010competitive.\u201d The initial and secondary outcome of this meta\u2010analysis was to evaluate the efficacy and safety of VA dual therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three studies and 668\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infected patients were included in this meta\u2010analysis. The crude eradication rate of VA dual therapy was 87.5% and 89.6% by ITT and PP analysis, respectively. No significant differences were observed regarding the VA dual therapy and vonoprazan\u2010amoxicillin\u2010clarithromycin (VAC) triple therapy according to ITT (RR\u00a0=\u00a00.99, 95% CI, 0.93\u20131.05,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.65) and PP (RR\u00a0=\u00a00.99, 95% CI, 0.94\u20131.05,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.82) analysis. The side effect of VA dual therapy was 19.1% (95% CI, 5.9\u201332.4), which was lower than that of VAC triple therapy but there was no statistical significance (RR\u00a0=\u00a00.75, 95% CI, 0.59\u20131.06,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.12).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      VA dual therapy shows acceptable efficacy, good safety and avoid unnecessary antibiotic use in the first\u2010line treatment for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection. However, its application in other regions need to be further explored.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.15917","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T12:48:40Z","timestamp":1655556520000},"page":"1666-1672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Amoxicillin\u2010vonoprazan dual therapy for\n                    <scp>\n                      <i>Helicobacter pylori<\/i>\n                    <\/scp>\n                    eradication: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"37","author":[{"given":"Yaobin","family":"Ouyang","sequence":"first","affiliation":[{"name":"Department Of Gastroenterology The First Affiliated Hospital of Nanchang University Nanchang 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