{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:30:18Z","timestamp":1782552618446,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The aim of this study was to assess the impact of body mass index (BMI) on the clinical and histological characteristics of patients with nonalcoholic fatty liver disease (NAFLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with clinically diagnosed NAFLD who received liver biopsy were retrospectively enrolled from 2007 to 2019. For comparison, all of the patients were divided into lean body mass (&lt;\u00a023\u00a0kg\/m<jats:sup>2<\/jats:sup>), overweight (23\u201324.9\u00a0kg\/m<jats:sup>2<\/jats:sup>), and obesity (BMI\u00a0\u2267\u00a025\u00a0kg\/m<jats:sup>2<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 572 patients with histologically confirmed NAFLD, including 40 (6.99%) lean body mass, 54 (9.44%) overweight, and 478 (83.57%) obese patients, were recruited. Obese NAFLD patients had significantly higher grade of steatosis (grade 3: 29.92% <jats:italic>vs<\/jats:italic> 22.22% <jats:italic>vs<\/jats:italic> 12.5%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and hepatocyte ballooning (grade 2: 14.85% <jats:italic>vs<\/jats:italic> 12.96% <jats:italic>vs<\/jats:italic> 12.5%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) than overweight and lean NAFLD patients. The prevalence of nonalcoholic steatohepatitis (NASH) was 22.5%, 25.93%, and 36.19% in lean, overweight, and obese NAFLD patients, respectively. Obesity was significantly associated with fibrosis severity (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). The fibrosis index based on four factors (FIB\u20104) score can identify NAFLD patients without significant fibrosis or with cirrhosis. The areas under the receiver\u2010operating characteristic curve of FIB\u20104 score to identify patients without significant fibrosis or with cirrhosis were 0.82 (95% confidence interval [CI]: 0.69\u20130.96) and 0.87 (95% CI: 0.76\u20130.99) in lean patients; 0.77 (95% CI: 0.61\u20130.93) and 0.81 (95% CI: 0.59\u20131.0) in overweight patients; and 0.77 (95% CI: 0.72\u20130.82) and 0.89 (95% CI: 0.85\u20130.92) in obese patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of NAFLD patients are obese, as defined by BMI. Obesity was significantly associated with NASH and hepatic fibrosis severity in patients with NAFLD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15936","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T01:08:40Z","timestamp":1657069720000},"page":"1901-1910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The impact of body mass index on clinicopathological features of nonalcoholic fatty liver disease in Taiwan"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9890-7596","authenticated-orcid":false,"given":"Chih\u2010Lin","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Renai Branch Taipei City Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Ming","family":"Tai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine E\u2010Da Hospital, I\u2010Shou University  Kaohsiung Taiwan"},{"name":"School of Medicine, College of Medicine I\u2010Shou University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2752-7051","authenticated-orcid":false,"given":"Jee\u2010Fu","family":"Huang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6202-0993","authenticated-orcid":false,"given":"Chun\u2010Jen","family":"Liu","sequence":"additional","affiliation":[{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Fen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Renai Branch Taipei City Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin\u2010Nan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Chia\u2010Yi Christian Hospital  Chia Yi 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