{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:27:11Z","timestamp":1773394031014,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NMRPD1F1531\u20103"],"award-info":[{"award-number":["NMRPD1F1531\u20103"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NMRPD1J0431\u20103"],"award-info":[{"award-number":["NMRPD1J0431\u20103"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NMRPD1M0451"],"award-info":[{"award-number":["NMRPD1M0451"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>In HBeAg negative chronic hepatitis B (CHB) patients, clinical relapse (CR) occurs more frequently, much earlier and often more severely after stopping tenofovir (TDF) and other nucleos(t)ide analogues (Nucs) than after stopping entecavir (ETV). It is unknown whether off\u2010Nuc hepatitis flare can be alleviated by switching from one Nuc to another.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HBeAg\u2010negative CHB patients who had stopped Nuc according to the APASL stopping rule and had been followed\u2010up for &gt;\u00a048\u00a0weeks after Nuc cessation were recruited. Patients were classified as four groups: ETV monotherapy (mono\u2010ETV), TDF monotherapy (mono\u2010TDF), switched to ETV (switch\u2010ETV), and switched to TDF (switch\u2010TDF). Both switch groups had switched to the replacement Nuc\u00a0&gt;\u00a012\u00a0weeks prior to end of therapy. Propensity score matching (PSM) was performed to minimize confounders among groups. Cox regression analysis was used to identify risks factors for off\u2010Nuc CR and flares.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1309 patients (1022 mono\u2010ETV, 219 mono\u2010TDF, 40 switch\u2010ETV and 28 switch\u2010TDF) were enrolled. The median time to CR was 39, 13, 38 and 14\u00a0weeks in mono\u2010ETV, mono\u2010TDF, switch\u2010ETV and switch\u2010TDF respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). After PSM, the mono\u2010ETV (adjusted HR: 0.39, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and switch\u2010ETV patients (adjusted HR: 0.41, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) had both significantly later occurrence and lower rates of CR and flare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, the incidence and timing of CR was determined by ETV or TDF in the last 3\u00a0months prior to end of treatment. Patients treated with non\u2010ETV\u2010Nuc switched to ETV\u00a0&gt;\u00a012\u00a0weeks before end of the original Nuc therapy may reduce\/defer CR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15966","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T08:03:58Z","timestamp":1658563438000},"page":"2164-2172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A switch from tenofovir to entecavir prior to hepatitis B treatment cessation is associated with a reduced risk of off\u2010therapy relapse: An observational study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0744-7123","authenticated-orcid":false,"given":"Chien\u2010Wei","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital, Linkou branch  Taoyuan Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3706-1259","authenticated-orcid":false,"given":"Wen\u2010Juei","family":"Jeng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital, Linkou branch  Taoyuan Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwai\u2010I","family":"Yang","sequence":"additional","affiliation":[{"name":"Genomic Research Center Academia Sinica  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8892-3341","authenticated-orcid":false,"given":"Yen\u2010Chun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital, Linkou branch  Taoyuan Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan 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