{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:51:35Z","timestamp":1780915895484,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T00:00:00Z","timestamp":1661040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Gastric IgG4\u2010related disease (IgG4\u2010RD) can mimic malignancy, submucosal tumors (SMT), and ulcers, leading to over\u2010triage and unnecessary medical interventions such as gastrectomy. The variability in the clinicopathological presentation of IgG4\u2010related disease is not yet well defined, posing a diagnostic challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following the PRISMA Extension for Scoping Reviews, we searched MEDLINE and EMBASE for all peer\u2010reviewed articles using keywords including \u201cgastritis,\u201d \u201cstomach,\u201d \u201cgastrointestinal stromal tumor,\u201d and \u201cIgG4\u2010RD\u201d from their inception to December 28, 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010nine articles, including 2 observational studies and 42 cases, were included in the systematic review. While bottom\u2010heavy lymphoplasmacytic mucosal infiltration is a characteristic finding of gastric IgG4\u2010RD, it was only present in less than half of the patients in the observational studies. Patients with gastric IgG4\u2010RD were more likely to be diagnosed with gastrointestinal stromal tumor (GIST), gastric cancer, or peptic ulcer disease and their clinical course involved resection (51.3%) or even gastrectomy. Diagnosis of gastric IgG4\u2010RD was most frequently made by post\u2010operative pathological analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This systematic review summarizes the current understanding of the characteristics of gastric IgG4\u2010RD. Increased awareness of gastric IgG4\u2010RD as a differential diagnosis of gastric SMT or ulcers among clinicians is crucial in order to reduce unnecessary high\u2010risk, invasive interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15980","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T04:43:15Z","timestamp":1660192995000},"page":"1865-1872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinicopathological characteristics of gastric IgG4\u2010related disease: Systematic scoping review"],"prefix":"10.1111","volume":"37","author":[{"given":"Haruki","family":"Sawada","sequence":"first","affiliation":[{"name":"Department of Medicine, John A. 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