{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:43:50Z","timestamp":1790613830424,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>We aim to assess the association between maternal hepatitis C virus (HCV) viral load and human immunodeficiency virus (HIV) coinfection and the risk for mother\u2010to\u2010child transmission (MTCT) among pregnant women infected with HCV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search of the Medline, Embase, Central, Science Citation Index Expanded (SCIE), Conference Proceedings Citation Index\u2010Science (CPCIS), Scopus, <jats:italic>Literature Latino\u2010Americana e do Caribe em Ci\u00eancias da Sa\u00fade<\/jats:italic> (LILACS), and WHO Global Index Medicus databases, from inception to June 21, 2022, was performed. Studies that reported the incidence HCV\u2010MTCT were included. Pooled effect estimates were calculated using the random\u2010effects model, and Holm\u2013Bonferroni correction was performed for multiple pooled associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The present meta\u2010analysis included 26 studies involving 4934 newborns with maternal HCV infection. Pregnant women with HCV viremia exhibited increased risk for MTCT (odds ratio [OR] 8.25 [95% confidence interval (CI) 4.65\u201314.63]) compared with those negative for HCV\u2010RNA. Multiple subgroup analysis revealed that the HCV viremia\/HIV\u2010positive group demonstrated the highest risk for HCV MTCT, followed by the HCV viremia mono\u2010infected group, while HCV\u2010RNA\u2010negative women demonstrated the lowest risk for HCV MTCT. Among females with HCV viremia, elevated risk for MTCT was found among subjects with a viral load \u2265\u00a06 log<jats:sub>10<\/jats:sub> copies\/mL compared with those with viral load &lt;\u00a06 log<jats:sub>10<\/jats:sub> copies\/mL (OR 4.58 [95% CI: 2.52\u20138.34]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of HCV MTCT was increased among pregnant women with detectable HCV viremia and was even higher in those with a viral load \u2265\u00a06 log<jats:sub>10<\/jats:sub> copies\/mL. HIV coinfection further increased the risk for HCV MTCT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15998","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T15:22:59Z","timestamp":1662477779000},"page":"177-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hepatitis C viral load and mother\u2010to\u2010child transmission: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9785-8980","authenticated-orcid":false,"given":"Songqing","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics and Epidemiology, School of Public Health Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics and Epidemiology, School of Public Health Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-8215","authenticated-orcid":false,"given":"Zilian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30359-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30385-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.05.016"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6914a2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6528a2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31825"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr6902a1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1123"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310328"},{"key":"e_1_2_6_11_1","first-page":"CD005546","article-title":"Caesarean section versus vaginal delivery for preventing mother to infant hepatitis C virus transmission","author":"McIntyre PG","year":"2006","journal-title":"Cochrane Database Syst. 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