{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T15:42:07Z","timestamp":1784389327460,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Considering the limitation of varying acid suppression of proton pump inhibitors, this study was aimed to assess the efficacy, safety, and dose\u2013effect relationship of keverprazan, a novel potassium\u2010competitive acid blocker, in the treatment of duodenal ulcer (DU) compared with lansoprazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, double\u2010blind, double\u2010dummy, multicenter, low\u2010dose, high\u2010dose, and positive\u2010drug parallel\u2010controlled study was conducted to verify the non\u2010inferiority of keverprazan (20 or 30\u00a0mg) to lansoprazole of 30\u00a0mg once daily for 4 to 6\u00a0weeks and dose\u2013effect relationship of keverprazan in the treatment of patients with active DU confirmed by endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 180 subjects randomized, including 55 cases in the keverprazan_20\u00a0mg group, 61 cases in the keverprazan_30\u00a0mg group, and 64 cases in the lansoprazole_30\u00a0mg group, 168 subjects (93.33%) completed the study. The proportions of healed DU subjects in the keverprazan_20\u00a0mg, keverprazan_30\u00a0mg, and lansoprazole_30\u00a0mg groups were respectively 87.27%, 90.16%, and 79.69% at week 4 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.4595) and were respectively 96.36%, 98.36%, and 92.19% at week 6 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.2577). The incidence of adverse events in the keverprazan_20\u00a0mg group was lower than that in the lansoprazole_30\u00a0mg (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0285) and keverprazan_30\u00a0mg groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0398).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Keverprazan was effective and non\u2010inferior to lansoprazole in healing DU. Based on the comparable efficacy and safety data, keverprazan of 20\u00a0mg once daily is recommended for the follow\u2010up study of acid\u2010related disorders. (Trial registration number: ChiCTR2100043455.)<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16000","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T06:18:48Z","timestamp":1662531528000},"page":"2060-2066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of keverprazan for duodenal ulcer: A phase II randomized, double\u2010blind, parallel\u2010controlled trial"],"prefix":"10.1111","volume":"37","author":[{"given":"Nian\u2010di","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Xiangya Hospital Central South University  Changsha Hunan Province 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