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This study aimed to evaluate the cost\u2010effectiveness of standard treatment with and without FMT therapy for mild\u2010to\u2010moderate active UC from the perspective of US healthcare provider.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 10\u2010year Markov model was developed to evaluate the costs and quality\u2010adjusted life\u2010years (QALYs) of standard treatment plus FMT therapy <jats:italic>versus<\/jats:italic> standard treatment alone. Model inputs were retrieved from publish data in literature. Base\u2010case and sensitivity analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the base\u2010case analysis, standard treatment plus FMT therapy was more effective than standard treatment alone (by 0.068 QALYs). Comparing to standard treatment alone, standard treatment plus FMT therapy varied from cost\u2010saving to incremental cost, subject to the number of FMT administrations. One\u2010way sensitivity analysis identified the relative risk of achieving remission with FMT therapy to be the most influential factor on the incremental cost\u2010effectiveness ratio of standard treatment plus FMT therapy. Monte\u2010Carlo simulations showed that standard treatment plus FMT therapy with 3 and 6 administrations per FMT course was cost\u2010effective (at willingness\u2010to\u2010pay threshold\u00a0=\u00a050\u00a0000 USD\/QALY) in 90.77% and 67.03% of time, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Standard treatment plus FMT therapy appears to be more effective in gaining higher QALYs than standard therapy alone for patients with mild\u2010to\u2010moderate active UC. Cost\u2010effectiveness of standard treatment plus FMT therapy is highly subject to the relative improvement in achieving remission with standard therapy plus FMT therapy and number of FMT administrations per FMT course.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16015","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T10:05:02Z","timestamp":1664618702000},"page":"70-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fecal microbiota transplantation for patients with active ulcerative colitis: A cost\u2010effectiveness analysis"],"prefix":"10.1111","volume":"38","author":[{"given":"Jiaqi","family":"Yao","sequence":"first","affiliation":[{"name":"School of Pharmacy, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginenus","family":"Fekadu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6850-4454","authenticated-orcid":false,"given":"Siew C","family":"Ng","sequence":"additional","affiliation":[{"name":"Microbiota I\u2010Center The Chinese University of Hong Kong  Hong Kong"},{"name":"Department of Medicine and Therapeutics, LKS Institute of Health Science, State Key Laboratory of Digestive Disease The Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5763-7403","authenticated-orcid":false,"given":"Joyce H S","family":"You","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32126-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6542a3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.09.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2015.1021353"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz104"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04234.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106146"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000893"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.03.045"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30182-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.20046"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2020-0242"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab178"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.12.009"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.07.011"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20580"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.043372"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5302.441"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.1.3.217"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5321.1708"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050516"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.032"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215734"},{"key":"e_1_2_8_27_1","first-page":"CD000543","article-title":"Oral 5\u2010aminosalicylic acid for induction of remission in ulcerative colitis","volume":"8","author":"Murray A","year":"2020","journal-title":"Cochrane Database Syst. 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