{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:24:15Z","timestamp":1782779055605,"version":"3.54.5"},"reference-count":73,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Liver involvement in celiac disease (CeD) is known but its various etiologies and the effect of gluten free diet (GFD) on it is understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, Medline and Embase databases from date of inception to March 7, 2022, to look for studies reporting on CeD and liver abnormalities. Pooled proportion of CeD patients with deranged transaminases, etiologies of various other liver diseases with CeD and the response to GFD were estimated. Subgroup analyses based on the age group, geographic distribution and duration of GFD were also carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total 42 studies (8976 patients) reported hyper\u2010transaminasemia in patients with celiac disease. The pooled proportion of patients with elevated transaminases was 21.42% (95% CI: 17.02\u201326.59, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a094%) overall, with similar prevalence among adults (21.20%) and children (21.51%). The commonest etiology was celiac hepatitis at 49.23% (95% CI: 30.09\u201368.59, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a087%). Compliance with GFD was noted in 90.27%. The proportion of CeD patients with liver abnormalities who showed response to GFD was 86.39% (95% CI: 80.04\u201390.95, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a074%) overall.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liver involvement was noted in 21.42% of CeD patients. Celiac hepatitis was reported in nearly half of them. Good compliance and response were noted with GFD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16039","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T10:44:30Z","timestamp":1666867470000},"page":"11-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Liver abnormalities in celiac disease and response to gluten free diet: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"38","author":[{"given":"Anuraag","family":"Jena","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Kumar\u2010M","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antriksh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chhagan Lal","family":"Birda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arup","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl","family":"Ramai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Utah Health  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2107-2156","authenticated-orcid":false,"given":"Antonio","family":"Facciorusso","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Gastroenterology Unit University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9277-5086","authenticated-orcid":false,"given":"Jayanta","family":"Samanta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.035345"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21949"},{"key":"e_1_2_5_4_1","first-page":"595","article-title":"Liver involvement in celiac disease","volume":"99","author":"Rubio\u2010Tapia A","year":"2008","journal-title":"Minerva Med."},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.11.013"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1380-z"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619844125"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000054"},{"key":"e_1_2_5_12_1","volume-title":"R: A language and environment for statistical computing","author":"Core Team R","year":"2021"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2019-300117"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301346"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1221"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.05.022"},{"key":"e_1_2_5_19_1","first-page":"522","article-title":"Varied presentation of celiac disease in Pakistani adults","volume":"23","author":"Abbas Z","year":"2013","journal-title":"J. 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