{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:10:56Z","timestamp":1787015456099,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H05081"],"award-info":[{"award-number":["17H05081"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>The incidence of early\u2010onset colorectal neoplasms has been increasing in both Western and Eastern countries. However, the risks and preventive factors for these neoplasms in Eastern countries remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The data of 5580 patients who underwent colonoscopy between 2016 and 2021 were retrospectively evaluated. The primary outcome was advanced colorectal neoplasm (ACRN), defined as advanced adenomas (adenoma\n                      <jats:bold>\u2265<\/jats:bold>\n                      10\u00a0mm, or with high\u2010grade dysplasia or villous component) or adenocarcinoma. The clinical factors associated with ACRNs were determined for each age category (\n                      <jats:bold>\u2264<\/jats:bold>\n                      50 and &gt;50\u00a0years), and the differences between the two categories were assessed. Odds ratios adjusted for age and sex were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1001 patients (age\n                      <jats:bold>\u2264<\/jats:bold>\n                      50\u00a0years), ACRN was found in 94 (9.4%). In this younger category, male sex (adjusted odds ratio [aOR]:2.34, 95% confidence interval [CI]:1.51\u20133.63) and a family history of colorectal cancer (aOR:2.14, 95% CI:1.17\u20133.89) were significantly associated with higher odds of developing ACRNs. ACRNs were detected in 726 (15.9%) of 4579 patients (age &gt;50\u00a0years). In the older age category, smoking (aOR:1.32, 95% CI:1.08\u20131.63) was significantly associated with a higher risk of ACRNs. Exercise of &gt;3.5 metabolic equivalent of task (METs) (aOR,0.80; 95% CI:0.67\u20130.96) was significantly associated with a lower risk of ACRNs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The development of early\u2010onset ACRNs was primarily associated with congenital factors, whereas that of late\u2010onset ACRNs was associated with acquired ones. Colonoscopy is recommended for young male patients, particularly for those with a family history of colorectal cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16045","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T14:17:05Z","timestamp":1666880225000},"page":"259-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk and preventive factors of early\u2010onset colorectal neoplasms: endoscopic and histological database analysis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4905-7046","authenticated-orcid":false,"given":"Junya","family":"Arai","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine University of Tokyo  Tokyo 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