{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:58:03Z","timestamp":1783421883386,"version":"3.54.6"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>We aimed to identify the long\u2010term clinical outcomes of and prognostic factors for intestinal Beh\u00e7et's disease (BD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 780 patients with intestinal BD between 1997 and 2021 was investigated to determine long\u2010term clinical outcomes and prognostic factors at an inflammatory bowel disease clinic at Severance Hospital, Seoul, Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the median follow\u2010up period of 12.7\u00a0\u00b1\u00a07.2\u00a0years, 5\u2010aminosalicylic acids, corticosteroids, immunomodulators, and anti\u2010tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) agents were required in 94.9%, 67.2%, 43.8%, and 14.6% of the patients, respectively. The cumulative rates of anti\u2010TNF\u2010\u03b1 use were 3.7%, 7.5%, 8.5%, 12.1%, 17.6%, and 24.0%, and those for abdominal surgery were 5.7%, 10.9%, 12.6%, 16.5%, 21.6%, and 28.3%, at 1, 3, 5, 10, 20, and 30\u00a0years, respectively, after initial diagnosis of intestinal BD. The cumulative rates of hospitalization were 11.8%, 21.9%, 27.9%, 38.8%, 54.4%, and 74.8%, and those of emergency room visits were 10.0%, 19.8%, 22.7%, 31.6%, 50.0%, and 65.0% at 1, 3, 5, 10, 20, and 30\u00a0years. Older age at primary diagnosis, previous appendectomy history, higher disease activity index for intestinal Beh\u00e7et's disease score, systemic BD, multiple intestinal ulcers, deep intestinal ulcers, higher C\u2010reactive protein, lower hemoglobin, and lower albumin levels were associated with poor prognosis. Married status, higher body mass index, oral ulceration, and arthritis were negatively associated with poor prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Data on the long\u2010term clinical outcomes of intestinal BD and their prognostic factors could guide physicians in patient monitoring and in optimizing individualized treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16056","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T11:54:27Z","timestamp":1667908467000},"page":"386-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Long\u2010term clinical outcomes of intestinal Beh\u00e7et's disease: A 30\u2010year cohort study at a tertiary hospital in South Korea"],"prefix":"10.1111","volume":"38","author":[{"given":"Jihye","family":"Park","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"},{"name":"Institute of Gastroenterology Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0699-6809","authenticated-orcid":false,"given":"Soo Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"},{"name":"Institute of Gastroenterology Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Jun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"},{"name":"Institute of Gastroenterology Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"},{"name":"Institute of Gastroenterology Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2282-8904","authenticated-orcid":false,"given":"Jae Hee","family":"Cheon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"},{"name":"Institute of Gastroenterology Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1","article-title":"Update on the diagnosis and management of Behcet's disease","volume":"7","author":"Rokutanda R","year":"2015","journal-title":"Open Access Rheumatol."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2090-4"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-020-01690-y"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.331"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1300-3"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2012.53.1.35"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20190349"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2351-9"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-016-2728-x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484084"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-016-2743-y"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2020.00013"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2022.63.2.148"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22991"},{"key":"e_1_2_5_16_1","first-page":"103","article-title":"Mimicry and deception in inflammatory bowel disease and intestinal behcet disease","volume":"8","author":"Grigg EL","year":"2012","journal-title":"Gastroenterol. 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