{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:18:24Z","timestamp":1769066304036,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Colorectal cancer (CRC) diagnosed following a cancer\u2010negative colonoscopy is termed as post\u2010colonoscopy CRC (PCCRC). The World Endoscopy Organization has recently standardized the definition of PCCRC\u20103Y (CRC developing within 3\u00a0years of a cancer\u2010negative colonoscopy). In the present study, we sought to assess PCCRC\u20103Y rate, perform root\u2010cause analyses, and identify factors associated with development of PCCRC at a tertiary referral hospital in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients undergoing colonoscopy from 2011 to 2018 were matched to a population\u2010based cancer register. PCCRC\u20103Y rate was assessed for years 2011\u20132015. All PCCRC cases that developed within 6\u201348\u00a0months after a cancer\u2010negative colonoscopy underwent root\u2010cause analyses. Descriptive statistics were used to summarize data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 17\u00a0828 patients undergoing colonoscopy, 367 CRC cases were diagnosed during the study period. This included nine PCCRC cases, which developed at a median of 14\u00a0months (range 7\u201334\u00a0months) after cancer\u2010negative colonoscopy. The PCCRC\u20103Y rate for years 2011\u20132015 was 2.16% (95% CI 0.91\u20135.15). All nine PCCRC cases were moderately or poorly differentiated adenocarcinomas; seven of nine were early\u2010stage CRC (stages I and II) and six of nine probably represented missed lesions at index colonoscopy despite an apparently adequate examination. History of inflammatory bowel disease (IBD) (odds ratio [OR] 21.9, 95% confidence interval [CI] 4.6\u2013103.7, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and diverticulosis (OR 5.4, 95% CI 1.4\u201320.5, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) were significantly associated with development of missed CRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our tertiary referral colonoscopy cohort, PCCRC\u20103Y rate was 2.16% (95% CI 0.91\u20135.15). IBD and diverticulosis were significantly associated with risk of PCCRC. The majority of PCCRC lesions were likely missed at index colonoscopy, despite an apparently adequate examination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16077","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:54:14Z","timestamp":1669596854000},"page":"740-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Post\u2010colonoscopy cancer rate at a tertiary referral hospital in Australia: A data linkage analysis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6334-9360","authenticated-orcid":false,"given":"Mehul","family":"Lamba","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4809-0928","authenticated-orcid":false,"given":"Myat Myat","family":"Khaing","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8188-9977","authenticated-orcid":false,"given":"Kimberley","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Appleyard","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Royal Brisbane and Women's Hospital  Brisbane Queensland 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