{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:13:25Z","timestamp":1790810005044,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313871"],"award-info":[{"award-number":["2017A030313871"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The combination of sorafenib and hepatic arterial infusion chemotherapy (HAIC) is expected to exert a synergistic anticancer effect. We conducted this systematic review to examine the efficacy and safety of sorafenib plus HAIC <jats:italic>vs<\/jats:italic> sorafenib alone for advanced hepatocellular carcinoma (HCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically searched the PubMed, Embase, and Cochrane Library with the following search terms: \u201csorafenib,\u201d \u201chepatic arterial infusion chemotherapy,\u201d \u201cHAIC,\u201d \u201cadvanced,\u201d \u201chepatocellular carcinoma,\u201d and \u201cHCC.\u201d Pooled hazard ratios (HRs) and 95% CIs were calculated for overall survival (OS) and progression\u2010free survival (PFS), and we calculated the pooled risk ratios (RRs) and 95% CIs for objective response rate (ORR) and adverse events (AEs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that sorafenib plus HAIC was associated with significantly better OS (HR, 0.56; 95% CI, 0.37\u20130.83; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), PFS (HR, 0.44; 95% CI, 0.27\u20130.72; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and ORR (RR, 3.77; 95% CI, 1.87\u20137.58; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) than sorafenib alone in advanced HCC. Grade 3\/4 AEs were more frequent in the sorafenib plus HAIC group, including leukopenia (RR, 4.54; 95% CI, 1.77\u201311.64; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), neutropenia (RR, 7.81; 95% CI, 3.36\u201318.16; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), thrombocytopenia (RR, 2.97; 95% CI, 1.98\u20134.46; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), anemia (RR, 2.24; 95% CI, 1.22\u20134.09; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), anorexia (RR, 2.37; 95% CI, 1.07\u20135.27; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), nausea (RR, 2.98; 95% CI, 1.19\u20137.42; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), and vomiting (RR, 3.99; 95% CI, 1.14\u201314.01; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sorafenib plus HAIC improved OS, PFS, and ORR compared with sorafenib alone in advanced HCC, with acceptable safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16088","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T17:25:41Z","timestamp":1671038741000},"page":"486-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sorafenib plus hepatic arterial infusion chemotherapy versus sorafenib alone for advanced hepatocellular carcinoma: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"38","author":[{"given":"Yin","family":"Long","sequence":"first","affiliation":[{"name":"Department of Hepatology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingdong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guan","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senlin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong\u2010Hong Kong Joint Laboratory for RNA Medicine, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9301-0181","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.12.041"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708857"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70285-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30207-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915745"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03555"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00808"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2015.1071354"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.018"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00608"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2019.12.001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000473887"},{"key":"e_1_2_6_15_1","volume-title":"Guidelines for hepatocellular carcinoma (version 2020)","author":"Chinese Society of Clinical Oncology (CSCO)","year":"2020"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514174"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw323"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30078-5"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.0250"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6198-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.211545"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1247132"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_6_29_1","first-page":"165","article-title":"Efficacy of sequential sorafenib plus hepatic arterial infusion chemotherapy in patients with Barcelona Clinic Liver Cancer stage B and C hepatocellular carcinoma: A retrospective single\u2010institution study","volume":"22","author":"Ikuta S","year":"2018","journal-title":"Contemp Oncol (Pozn)"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jimed.2019.07.005"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001384"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2021.101663"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.06.026"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.384"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-1340"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1695-6"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-010-1914-4"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4291"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.356"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cad.0000131684.06390.fe"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314138"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.02.008"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8DT00838H"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29086"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.019"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy308"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0022"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01963"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.16088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.16088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.16088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T12:28:09Z","timestamp":1692707289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.16088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,16]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/jgh.16088"],"URL":"https:\/\/doi.org\/10.1111\/jgh.16088","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,16]]},"assertion":[{"value":"2022-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}