{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:31:43Z","timestamp":1790220703853,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Appendectomy is associated with various diseases, but whether it increases the risk of colorectal cancer (CRC) remains uncertain. We conducted a systematic review and meta\u2010analysis aimed at investigating the suggested correlation between appendectomy and CRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic retrieval was performed using the PubMed, Embase, Cochrane library, Web of Science, and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> databases up to May 4, 2022, for studies reported the influence of appendectomy on CRC, colon cancer (CC) or rectal cancer (RC). Odd ratios (ORs) and 95% confidence intervals (CIs) of CRC after appendectomy were pooled using the random effects model. Subgroup analyses were carried on by region, sex, and tumor location.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our search identified 1743 articles, of which 22 studies from three continents published between 1964 and 2022 were eligible for inclusion. Overall, people with appendectomy had a higher risk of CRC (OR\u00a0=\u00a01.31; 95% CI [1.05, 1.62]). But the risk for Europeans was not significant (OR\u00a0=\u00a00.94; 95% CI [0.87, 1.02]; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%), while for Americans and Asians, appendectomy would increase the risk of CRC (OR\u00a0=\u00a01.68; 95% CI [1.15, 2.44]; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a065% and OR\u00a0=\u00a01.46; 95% CI [1.04, 2.05]; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a098%), especially in females and in developing countries. It is worth noting that appendectomy might be a protective factor for CC in European women (OR\u00a0=\u00a00.87; 95% CI [0.77, 0.98]; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Appendectomy may be a risk factor for CRC, with varying degrees in different populations. More high\u2010quality cross\u2010regional studies are needed for better clinical decision making.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16108","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T18:24:09Z","timestamp":1673634249000},"page":"350-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Risk of colorectal cancer after appendectomy: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4302-9869","authenticated-orcid":false,"given":"Zhuhui","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; State Key Laboratory for Oncogenes and Related Genes; Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai 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