{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:45:32Z","timestamp":1783464332064,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Immunoglobulin G4\u2010related sclerosing cholangitis (IgG4\u2010SC) is considered a biliary manifestation of IgG4\u2010related diseases. However, there has been a controversy on the clinical outcomes according to the location of the involved bile duct. We therefore compared the clinical outcomes and long\u2010term prognosis of IgG4\u2010SC with proximal bile duct involvement (proximal IgG4\u2010SC) and IgG4\u2010SC with distal bile duct involvement (distal IgG4\u2010SC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the data of patients with IgG4\u2010SC that were prospectively collected at 10 tertiary centers between March 2002 and October 2020. Clinical manifestations, outcomes, association with autoimmune pancreatitis (AIP), steroid\u2010responsiveness, and relapse of IgG4\u2010SC were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 148 patients (proximal IgG4\u2010SC, <jats:italic>n<\/jats:italic>\u00a0=\u00a059; distal IgG4\u2010SC, <jats:italic>n<\/jats:italic>\u00a0=\u00a089) were analyzed. The median age was 65\u00a0years (IQR, 56.25\u201371), and 86% were male. The two groups were similar in terms of jaundice at initial presentation (51% <jats:italic>vs<\/jats:italic> 65%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.082) and presence of elevated serum IgG4 (66% <jats:italic>vs<\/jats:italic> 70%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.649). The two groups showed significant differences in terms of steroid\u2010responsiveness (91% <jats:italic>vs<\/jats:italic> 100%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008), association with AIP (75% <jats:italic>vs<\/jats:italic> 99%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), and occurrence of liver cirrhosis (9% <jats:italic>vs<\/jats:italic> 1%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.034). During a median follow\u2010up of 64\u00a0months (IQR, 21.9\u201384.7), the cumulative relapse\u2010free survival was significantly different between the two groups (67% <jats:italic>vs<\/jats:italic> 79% at 5\u00a0years; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Relapse of IgG4\u2010SC frequently occurred during follow\u2010up. Proximal IgG4\u2010SC and distal IgG4\u2010SC had different long\u2010term outcomes in terms of steroid\u2010responsiveness, occurrence of liver cirrhosis, and recurrence. It may be advantageous to determine the therapeutic and follow\u2010up strategies according to the location of bile duct involvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16136","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T05:39:21Z","timestamp":1675057161000},"page":"648-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of the long\u2010term outcomes between proximal and distal IgG4\u2010related sclerosing cholangitis: A multicenter cohort study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8664-4090","authenticated-orcid":false,"given":"Sung Hyun","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, University of Ulsan College of Medicine Asan Medical Center  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Jun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Ulsan College of Medicine Asan Medical Center  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9911-8823","authenticated-orcid":false,"given":"Jin\u2010Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Inha University School of Medicine  Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai Hoon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal medicine, Hanyang University Hospital Hanyang University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5039-8182","authenticated-orcid":false,"given":"Min Jae","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ajou University School of Medicine  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Bae","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Nah","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Soonchunhyang University School of Medicine  Bucheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Jeonbuk National University Medical School Research Institute of Clinical Medicine of Jeonbuk National University\u2010Biomedical Research Institute of Jeonbuk National University Hospital  Jeonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Kwang","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jeju National University School of Medicine  Jeju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital Hallym University College of Medicine  Gyeonggi\u2010do South 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