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In this study, the effects of aging and non\u2010alcoholic steatohepatitis on the skeletal muscle, and the interaction between the liver and muscle were investigated using a diet\u2010induced non\u2010alcoholic steatohepatitis model in senescence\u2010accelerated mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of four groups of senescence\u2010accelerated mice and the control mice were fed either a non\u2010alcoholic steatohepatitis\u2010inducing or control diet, and their livers and skeletal muscles were removed for examinations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the senescence\u2010accelerated\/non\u2010alcoholic steatohepatitis group, serum level of alanine aminotransferase was markedly elevated and histopathology of non\u2010alcoholic steatohepatitis was significant. Skeletal muscles were also markedly atrophied. The expression of the ubiquitin ligase\n                      <jats:italic>Murf1<\/jats:italic>\n                      in the muscle was significantly increased with muscle atrophy, while that of\n                      <jats:italic>Tnfa<\/jats:italic>\n                      was not significantly different. In contrast, the hepatic\n                      <jats:italic>Tnfa<\/jats:italic>\n                      expression and serum TNF\u2010\u03b1 levels were significantly increased in the senescence\u2010accelerated\/non\u2010alcoholic steatohepatitis group. These results suggest that liver\u2010derived TNF\u2010\u03b1 might promote muscle atrophy associated with steatohepatitis and aging through Murf\u20101. The metabolomic analysis of skeletal muscle indicated higher spermidine and lower tryptophan levels in the steatohepatitis\u2010diet group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings of this study revealed an aspect of liver\u2013muscle interaction, which might be important in developing treatments for sarcopenia associated with liver diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16171","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T22:39:26Z","timestamp":1678315166000},"page":"800-808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Skeletal muscle atrophy is exacerbated by steatotic and fibrotic liver\u2010derived TNF\u2010\u03b1 in senescence\u2010accelerated 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