{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:39:08Z","timestamp":1778755148126,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Although acute upper gastrointestinal bleeding (UGIB) can lead to anemia, evidence regarding the effects of oral iron supplementation on UGIB\u2010induced anemia following discharge remains lacking. The present study aimed to investigate the effects of oral iron supplementation on hemoglobin response and iron storage in patients with anemia secondary to nonvariceal UGIB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized controlled trial included 151 patients with nonvariceal UGIB who had anemia at discharge. Patients were assigned to a 1:1 block in which they were either administered 6\u00a0weeks of 600\u00a0mg\/d oral ferrous fumarate (treatment group, <jats:italic>n<\/jats:italic>\u00a0=\u00a077) or treated without iron supplementation (control group, <jats:italic>n<\/jats:italic>\u00a0=\u00a074). The primary outcome was composite hemoglobin response (hemoglobin elevation greater than 2\u00a0g\/dL or no anemia at the end of treatment [EOT]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of patients achieving composite hemoglobin response was greater in the treatment group than in the control group (72.7% <jats:italic>vs<\/jats:italic> 45.9%; adjusted risk ratio [RR], 2.980; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004). At EOT, the percentage change in the hemoglobin level (34.2\u00a0\u00b1\u00a024.8% <jats:italic>vs<\/jats:italic> 19.4\u00a0\u00b1\u00a019.9%; adjusted coefficient, 11.543; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) was significantly higher in the treatment group than in the control group; however, the proportions of patients with a serum ferritin level &lt;30\u00a0\u03bcg\/L and a transferrin saturation &lt;16% were lower in the treatment group (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). No significant differences in treatment\u2010associated adverse effects and adherence rates were observed between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oral iron supplementation exerts beneficial effects on anemia and iron storage following nonvariceal UGIB without significantly impacting rates of adverse effects or adherence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16185","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T02:03:03Z","timestamp":1680228183000},"page":"1283-1291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Role of oral iron supplementation for anemia secondary to acute nonvariceal upper gastrointestinal bleeding: a randomized controlled trial"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0158-2685","authenticated-orcid":false,"given":"Arunchai","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Hatyai Hospital  Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manus","family":"Rugivarodom","sequence":"additional","affiliation":[{"name":"Siriraj GI Endoscopy Center, Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuttanit","family":"Pungpipattrakul","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hatyai Hospital  Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keerati","family":"Akarapatima","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Hatyai Hospital  Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Komsai","family":"Suwanno","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Hatyai Hospital  Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attapon","family":"Rattanasupar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Hatyai Hospital  Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bancha","family":"Ovartlarnporn","sequence":"additional","affiliation":[{"name":"NKC Institute of Gastroenterology and Hepatology, Faculty of Medicine, Songklanagarind Hospital Prince of Songkla University  Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varayu","family":"Prachayakul","sequence":"additional","affiliation":[{"name":"Siriraj GI Endoscopy Center, Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-1795"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316276"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1393172"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211801"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2015.02.012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.3.316"},{"key":"e_1_2_7_8_1","first-page":"885","article-title":"Long\u2010term follow\u2010up of older patients with iron deficiency anemia after a negative GI evaluation","volume":"91","author":"Gordon S","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312023292303"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.10.1427"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15327"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12556"},{"key":"e_1_2_7_13_1","unstructured":"WHO\/UNICEF\/UNU.Iron deficiency anemia: assessment prevention and control. 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