{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:25:53Z","timestamp":1764937553090,"version":"3.41.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH172"],"award-info":[{"award-number":["ZR2021MH172"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>As a result of improved survival, cancer survivors continue to remain at risk of developing second primary malignancies (SPMs). However, the association between first primary pancreatic neuroendocrine neoplasms (PanNENs) and SPMs has not been thoroughly investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Surveillance, Epidemiology, and End Results\u201018 database, patients histologically diagnosed with PanNENs as their first malignancy between 2000 and 2018 were identified. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) and excess absolute risks per 10\u00a0000 person\u2010years of SPMs were calculated to estimate the risk of being diagnosed with subsequent cancers compared with the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 489 (5.7%) PanNENs survivors developed an SPM during the follow up, with a median latency between first and second cancer diagnoses of 32.0\u00a0months. The overall SIR of SPMs was 1.30 (95% CI: 1.19, 1.42) and the excess absolute risk was 35.67 cases per 10\u00a0000 person\u2010years in comparison with the general population. Age 25\u201364\u00a0years at PanNENs diagnosis was associated with statistically higher risks for SPMs of all cancers combined. Latency stratification was significant for elevated SPMs risk between 2\u201323 and 84+\u00a0months after diagnosis. White patients were found to have a significantly increased incidence of SPMs (SIR: 1.23, 95% CI: 1.11, 1.35), mainly owing to the higher risk of stomach, small intestine, pancreas, kidney and renal pelvis, and thyroid cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pancreatic neuroendocrine neoplasms survivors experience a significant increase in the burden of SPMs compared with the reference population. The heightened relative risk calls for careful long\u2010term scrutiny as part of survivorship care plans.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16201","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T10:52:30Z","timestamp":1682679150000},"page":"1474-1484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk of second primary malignancies in survivors of pancreatic neuroendocrine neoplasms from 2000 to 2018"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6177-1883","authenticated-orcid":false,"given":"Zhen","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery Qingdao Municipal Hospital, Qingdao University  Qingdao China"},{"name":"Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianshuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Qingdao Women and Children's Hospital, Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiming","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery Qingdao Municipal Hospital, Qingdao University  Qingdao China"},{"name":"Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangjun","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery Qingdao Municipal Hospital, Qingdao University  Qingdao China"},{"name":"Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21731"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0133"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.23130"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac091"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-021-01029-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyac049"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.12.052"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0589"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.24750"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0465"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10327"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw661"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-01940-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2018.0501"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.4531"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9098(200012)75:4<306::AID-JSO14>3.0.CO;2-3"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.dld.2020.09.031","article-title":"Second primary neoplasms in patients with lung and gastroenteropancreatic neuroendocrine neoplasms: data from a retrospective multi\u2010centric study","volume":"53","author":"Massironi S","year":"2021","journal-title":"Digest. 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