{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:00:57Z","timestamp":1792008057617,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Hepatic decompensation is a major complication of liver cirrhosis. We validated the predictive performance of the newly proposed CHESS\u2010ALARM model to predict hepatic decompensation in patients with hepatitis B virus (HBV)\u2010related cirrhosis and compared it with other transient elastography (TE)\u2010based models such as liver stiffness\u2010spleen size\u2010to\u2010platelet (LSPS), portal hypertension (PH), varices risk scores, albumin\u2010bilirubin (ALBI), and albumin\u2010bilirubin\u2010fibrosis\u20104 (ALBI\u2010FIB\u20104).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four hundred eighty\u2010two patients with HBV\u2010related liver cirrhosis between 2006 and 2014 were recruited. Liver cirrhosis was clinically or morphologically defined. The predictive performance of the models was assessed using a time\u2010dependent area under the curve (tAUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 48 patients (10.0%) developed hepatic decompensation (median 93\u00a0months). The 1\u2010year predictive performance of the LSPS model (tAUC\u00a0=\u00a00.8405) was higher than those of the PH model (tAUC\u00a0=\u00a00.8255), ALBI\u2010FIB\u20104 (tAUC\u00a0=\u00a00.8168), ALBI (tAUC\u00a0=\u00a00.8153), CHESS\u2010ALARM (tAUC\u00a0=\u00a00.8090), and variceal risk score (tAUC\u00a0=\u00a00.7990). The 3\u2010year predictive performance of the LSPS model (tAUC\u00a0=\u00a00.8673) was higher than those of the PH risk score (tAUC\u00a0=\u00a00.8670), CHESS\u2010ALARM (tAUC\u00a0=\u00a00.8329), variceal risk score (tAUC\u00a0=\u00a00.8290), ALBI\u2010FIB\u20104 (tAUC\u00a0=\u00a00.7730), and ALBI (tAUC\u00a0=\u00a00.7451). The 5\u2010year predictive performance of the PH risk score (tAUC\u00a0=\u00a00.8521) was higher than those of the LSPS (tAUC\u00a0=\u00a00.8465), varices risk score (tAUC\u00a0=\u00a00.8261), CHESS\u2010ALARM (tAUC\u00a0=\u00a00.7971), ALBI\u2010FIB\u20104 (tAUC\u00a0=\u00a00.7743), and ALBI (tAUC\u00a0=\u00a00.7541). However, there was no significant difference in the predictive performance among all models at 1, 3, and 5\u00a0years (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The CHESS\u2010ALARM score was able to reliably predict hepatic decompensation in patients with HBV\u2010related liver cirrhosis and showed similar performance to the LSPS, PH, varices risk scores, ALBI, and ALBI\u2010FIB\u20104.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16210","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T22:40:13Z","timestamp":1684190413000},"page":"1372-1380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Noninvasive risk assessment of hepatic decompensation in patients with hepatitis B virus\u2010related liver cirrhosis"],"prefix":"10.1111","volume":"38","author":[{"given":"David Sooik","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5363-2496","authenticated-orcid":false,"given":"Beom Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Yonsei Liver Center, Severance Hospital Yonsei University Health System  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2371-0967","authenticated-orcid":false,"given":"Jae Seung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of 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