{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:10:50Z","timestamp":1787015450702,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>There is a paucity of evidence regarding non\u2010anemic iron deficiency as a predictor for colorectal cancer and therefore the indication for endoscopic evaluation. This study explores the rates of malignancy in adults with iron deficiency with and without anemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective multicenter diagnostic cohort study was conducted across two Australian health services. All cases that underwent both esophagogastroduodenoscopy and colonoscopy between September 1, 2018, and December 31, 2019, for the investigation of iron deficiency were included, and the cohort was divided into anemic and non\u2010anemic arms. Multivariate binomial logistic regression was performed to establish clinical characteristics associated with neoplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five hundred eighty\u2010four patients underwent endoscopic evaluation over a 16\u2010month period. There was a significantly higher rate of malignancy in the iron deficiency anemia arm as compared with those without anemia (8.76%\n                      <jats:italic>vs<\/jats:italic>\n                      1.20%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). Gastrointestinal pathology to account for iron deficiency was identified in &gt;\u00a060% of the total cohort. The presence of anemia (odds ratio [OR] 6.87,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) and male gender (OR 3.01,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01) were significant predictors of malignancy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that anemic iron deficiency confers a significantly greater risk of gastrointestinal cancer compared with non\u2010anemic iron deficiency. Additionally, over 60% of patients had gastrointestinal pathology to account for iron deficiency overall, supporting the need to perform baseline endoscopy in patients with iron deficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16215","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T23:00:10Z","timestamp":1684364410000},"page":"1530-1534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence of gastrointestinal malignancy in non\u2010anemic iron deficiency and significance for endoscopic screening: A Western Australian multicenter cohort study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0831-7136","authenticated-orcid":false,"given":"Samantha","family":"Hodges","sequence":"first","affiliation":[{"name":"Fiona Stanley Fremantle Hospitals Group  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Attree","sequence":"additional","affiliation":[{"name":"Fiona Stanley Fremantle Hospitals Group  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5013-956X","authenticated-orcid":false,"given":"Sherman","family":"Picardo","sequence":"additional","affiliation":[{"name":"Royal Perth Bentley Group  Perth Western Australia Australia"},{"name":"Curtin University  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Faithfull","sequence":"additional","affiliation":[{"name":"Royal Perth Bentley Group  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"McElholm","sequence":"additional","affiliation":[{"name":"Rockingham General Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krish","family":"Ragunath","sequence":"additional","affiliation":[{"name":"Royal Perth Bentley Group  Perth Western Australia Australia"},{"name":"Curtin University  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Cancer in Australia 2017","author":"Australian Institute of Health and Welfare","year":"2017"},{"key":"e_1_2_7_3_1","volume-title":"Australian Cancer Incidence and Mortality (ACIM) Books: Colorectal Cancer (Also Called Bowel Cancer)","author":"Australian Institute of Health and Welfare","year":"2017"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01214-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja18.00142"},{"key":"e_1_2_7_6_1","volume-title":"Clinical Practice Guidelines for the Prevention, Early Detection and Management of Colorectal Cancer","author":"Cancer Council Australia Colorectal Cancer Guidelines Working Party","year":"2022"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200511000-00008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-9069-x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000687"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000687"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.06.046"},{"key":"e_1_2_7_12_1","first-page":"1","article-title":"British Society of Gastroenterology guidelines for the management of iron deficiency anaemia in adults","author":"Snook J","year":"2021","journal-title":"Br. Med. J."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2008.01785.x"},{"key":"e_1_2_7_14_1","first-page":"1","article-title":"Refinement and validation of the IDIOM score for predicting the risk of gastrointestinal cancer in iron deficiency anaemia","volume":"7","author":"Almilaji O","year":"2020","journal-title":"Br. Med. J."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2019.12.015"},{"key":"e_1_2_7_16_1","first-page":"1","article-title":"Iron deficiency and symptoms in women aged 20\u201349\u00a0years and relation to upper gastrointestinal and colon cancers","volume":"9","author":"Szpahowski j, Tucker L.","year":"2022","journal-title":"British Med. J. Open Gastroenterol."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15467"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.8.1102"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00430.x"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.16215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T02:56:26Z","timestamp":1748919386000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.16215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,17]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/jgh.16215"],"URL":"https:\/\/doi.org\/10.1111\/jgh.16215","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,17]]},"assertion":[{"value":"2022-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}