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We report the burden of pancreatic cancer and its attributable risk factors in the Middle East and North Africa (MENA) region, from 1990 to 2019, by age, sex, and socio\u2010demographic index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Publicly available data from the Global Burden of Disease 2019 study were used to report the incidence, deaths, and disability\u2010adjusted life years (DALYs) attributable to pancreatic cancer, as counts and age\u2010standardized rates with 95% uncertainty intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 2019, pancreatic cancer had an age\u2010standardized incidence rate of 5.3 and a death rate of 5.5 (per 100\u00a0000) in MENA, which have increased by 97.5% and 93.4%, respectively, since 1990. There were 563.6 thousand DALYs attributable to pancreatic cancer in 2019, with an age\u2010standardized DALY rate of 123.0, which has increased by 84.9% since 1990. The highest number of incident cases was found in the 60\u201364 and 65\u201369 age groups, among male and female, respectively. In addition, the MENA\/global DALY ratios were higher in all age groups for both sexes in 2019, than they were in 1990. There was a positive association between socio\u2010demographic index and the burden of pancreatic cancer. Smoking, high fasting plasma glucose, and high body mass index were responsible for 19.2%, 9.3%, and 9.3% of the attributable DALYs in 2019, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was a clear and substantial increase in the burden of pancreatic cancer in the MENA region. Prevention programs should be implemented in the region that target these three risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16217","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T07:06:00Z","timestamp":1684825560000},"page":"1535-1545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The burden of pancreatic cancer and its attributable risk factors in the Middle East and North Africa region, 1990\u20132019"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-9720","authenticated-orcid":false,"given":"Seyed Aria","family":"Nejadghaderi","sequence":"first","affiliation":[{"name":"Research Center for Integrative Medicine in Aging, Aging Research Institute Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"School of Medicine Shahid Beheshti University of Medical Sciences  Tehran 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