{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:04:30Z","timestamp":1790795070131,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["22K15974"],"award-info":[{"award-number":["22K15974"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Pemafibrate, a selective peroxisome proliferator activated receptor \u03b1 modulator, has been shown to improve liver function among nonalcoholic fatty liver disease (NAFLD) patients with dyslipidemia. The aim of this retrospective study is to identify predictors of pemafibrate efficacy in NAFLD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 75 NAFLD patients with dyslipidemia who received pemafibrate twice per day for 48\u00a0weeks were enrolled in this study. We used the FibroScan\u2010aspartate aminotransferase (FAST) score as a benchmark for treatment efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median FAST score significantly decreased from 0.96 at baseline to 0.93 at week 48 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Significant improvements in levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma\u2010glutamyl transferase (GGT), and triglycerides were also noted. The serum level of GGT at baseline was correlated with change in FAST score (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.22, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.049). Changes in AST, ALT, and GGT were positively correlated with change in FAST score (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.71, <jats:italic>r<\/jats:italic>\u00a0=\u00a00.61, and <jats:italic>r<\/jats:italic>\u00a0=\u00a00.38). Multivariate analyses identified age and GGT level at baseline as significantly associated with improvement of FAST score by pemafibrate therapy (odds ratio 1.11, 1.02, respectively). Patients over 50\u00a0years of age and with a GGT of 90\u00a0IU\/L or higher showed significantly greater improvement in the FAST score than other groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pemafibrate improves the FAST score of NAFLD patients with complicating dyslipidemia, especially in older patients with high GGT level. GGT is useful as an indicator of optimal treatment choice for NAFLD patients with dyslipidemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16222","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T03:44:33Z","timestamp":1684899873000},"page":"1743-1749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Gamma\u2010glutamyl transferase predicts pemafibrate treatment response in non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"38","author":[{"given":"Yusuke","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto 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