{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T16:25:56Z","timestamp":1775838356162,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2020R1A2C1010786"],"award-info":[{"award-number":["2020R1A2C1010786"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2020R1A5A2019210"],"award-info":[{"award-number":["2020R1A5A2019210"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>We evaluated the associations between gastric cancer (GC) family history (FH) and colorectal cancer (CRC) risk and between CRC FH and GC\/gastric adenoma risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data of participants who underwent national cancer screening between 2013 and 2014. Participants with GC or CRC FH in first\u2010degree relatives (<jats:italic>n<\/jats:italic>\u00a0=\u00a01\u2009172\u2009750) and those without cancer FH (<jats:italic>n<\/jats:italic>\u00a0=\u00a03\u2009518\u2009250) were matched 1:3 by age and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1\u2009172\u2009750 participants with a FH, 871\u2009104, 264\u2009040, and 37\u2009606 had FHs of only GC, only CRC, and both GC and CRC, respectively. The median follow\u2010up time was 4.8\u00a0years. GC and CRC FHs were associated with increased GC and CRC risks, respectively. GC FH was associated with CRC risk (adjusted hazard ratio 1.05; 95% confidence interval [CI] 1.01\u20131.10), whereas CRC FH was not associated with the risk of GC or gastric adenoma. However, gastric adenoma risk increased 1.62\u2010fold (95% CI 1.40\u20131.87) in participants with FHs of both GC and CRC, demonstrating a significant difference with the 1.39\u2010fold (95% CI 1.34\u20131.44) increase in participants with only GC FH. Furthermore, GC risk increased by 5.32 times (95% CI 1.74\u201316.24) in participants with FHs of both GC and CRC in both parents and siblings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GC FH was significantly associated with a 5% increase in CRC risk. Although CRC FH did not increase GC risk, FH of both GC and CRC further increased the risk of gastric adenoma. FHs of GC and CRC may affect each other's neoplastic lesion risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16251","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T04:06:36Z","timestamp":1685592396000},"page":"1787-1793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mutual association between family history of gastric and colorectal cancer and risk of gastric and colorectal cancer"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1963-7170","authenticated-orcid":false,"given":"Yoon Suk","family":"Jung","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai Thi Xuan","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Hanyang University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Hanyang University College of Medicine  Seoul Republic of Korea"},{"name":"Hanyang Institute of Bioscience and Biotechnology Hanyang University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2550-913X","authenticated-orcid":false,"given":"Chang Mo","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine Ewha Womans University  Seoul Republic of Korea"},{"name":"Inflammation\u2010Cancer Microenvironment Research Center, College of Medicine Ewha Womans University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.2014.863713"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt280"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i13.2435"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0075-y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2011.2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.09.017"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0010065"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-003-0322-z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21027"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000072335"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2007.48.6.981"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910540509"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000127"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.07.006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.03108.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.11.1764"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2020.263"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl210419"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2021.044"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/1.8.559"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1500.1999.99020.x"},{"key":"e_1_2_7_23_1","first-page":"99","article-title":"Aberration of p53 and DCC in gastric and colorectal cancer","volume":"7","author":"Kataoka M","year":"2000","journal-title":"Oncol. 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