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The detailed epigenomic changes during fat accumulation in liver are not clear yet. Here, we performed ChIP\u2010Seq analysis in the liver tissues of high\u2010fat diet and regular chow diet mice and investigated the dynamic landscapes of H3K27ac and H3K9me3 marks on chromatin. We find that the activated typical enhancers marked with H3K27ac are enriched on lipid metabolic pathways in fat liver; however, super enhancers do not change much. The regions covered with H3K9me3 repressive mark seem to undergo great changes, and its peak number and intensity both decrease in fat liver. The enhancers located in lost H3K9me3 regions are enriched in lipid metabolism and inflammatory pathways; and motif analysis shows that they are potential targets for transcription factors involved in metabolic and inflammatory processes. Our study has revealed that H3K9me3 may play an important role during the pathogenesis of NAFLD through regulating the accessibility of enhancers.<\/jats:p>","DOI":"10.1111\/jgh.16252","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:41:16Z","timestamp":1687135276000},"page":"1426-1437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Removal of epigenetic repressive mark on inflammatory genes in fat liver"],"prefix":"10.1111","volume":"38","author":[{"given":"La\u2010Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Renmin Hospital of Wuhan University Wuhan University  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Frontier Science Center for Immunology and Metabolism, Hubei Key Laboratory of Cell Homeostasis, Hubei 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