{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:48:05Z","timestamp":1787503685188,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T00:00:00Z","timestamp":1686355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The socioeconomic burden of alcohol\u2010related liver disease has been increasing worldwide. Its prevalence is underestimated, and patients with alcohol\u2010related liver disease are rarely diagnosed in the earlier phase of the disease spectrum. Alcoholic hepatitis is a distinct syndrome with life\u2010threatening signs of systemic inflammation. In severe alcoholic hepatitis, prednisolone is indicated as the first\u2010line treatment even with the possibility of various complications. Early liver transplantation can be another option for highly selected patients with a null response to prednisolone. Most importantly, abstinence is the mainstay of long\u2010term care, but relapse is frequent among patients. Recent findings on the pathogenesis of alcoholic hepatitis have enabled us to discover new therapeutic targets. Preventing hepatic inflammation, reducing oxidative stress, improving gut dysbiosis, and enhancing liver regeneration are the main targets of emerging therapies. Herein, we review the pathogenesis, current treatment, and barriers to successful clinical trials of alcoholic hepatitis. Additionally, clinical trials for alcoholic hepatitis, either ongoing or recently completed, will be briefly introduced.<\/jats:p>","DOI":"10.1111\/jgh.16257","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T07:28:50Z","timestamp":1686382130000},"page":"1218-1226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Current and future treatment for alcoholic\u2010related liver diseases"],"prefix":"10.1111","volume":"38","author":[{"given":"Eileen L.","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hanyang University College of Medicine  Seoul Republic of Korea"},{"name":"Hanyang Institute of Bioscience and Biotechnology Hanyang University  Seoul Republic of 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