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Alcohol abstinence remains the standard of care for promoting liver transplantation for ALD and for preventing posttransplant graft loss. However, efficient monitoring methods are still being developed due to the limitations of traditional biomarkers, interviews, and questionnaires. The development of alcohol biomarkers has shifted from detecting alcohol and methanol to indirect byproducts, and to current mid\u2010term and long\u2010term direct alcohol metabolites, which provide higher accuracy and cover almost all types of alcohol relapse detection. However, in most clinical studies, biomarkers are used and validated in healthy individuals and alcohol use disorder (AUD) patients and for pretransplant evaluations. The evidence for their use in posttransplant abstinence monitoring is still lacking, but it is crucial for early detection of alcohol relapse and initiating intervention. This review aims to summarize the current evidence of the use of biomarkers for monitoring sobriety and alcohol relapse after liver transplantation, as well as to cover the diagnostic accuracy, detection window, and optimal multidisciplinary strategies.<\/jats:p>","DOI":"10.1111\/jgh.16269","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T21:24:44Z","timestamp":1687641884000},"page":"1227-1232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Biomarkers for monitoring alcohol sobriety after liver transplantation for alcoholic liver disease"],"prefix":"10.1111","volume":"38","author":[{"given":"Jiang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Surgery, LKS Faculty of Medicine and HKU\u2010Shenzhen Hospital The University of Hong Kong  Hong Kong Hong Kong"},{"name":"Hepato\u2010pancreato\u2010biliary Center, Beijing Tsinghua Changgung Hospital Tsinghua 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