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This study aimed to clarify whether apoA2 isoforms were as useful as <jats:italic>N<\/jats:italic>\u2010benzoyl\u2010<jats:italic>p<\/jats:italic>\u2010aminobenzoic acid (BT\u2010PABA) test for exocrine pancreatic dysfunction markers in patients with early chronic pancreatitis (ECP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty consecutive patients with functional dyspepsia with pancreatic enzyme abnormalities (FD\u2010P) (<jats:italic>n<\/jats:italic>\u00a0=\u00a018), with ECP (<jats:italic>n<\/jats:italic>\u00a0=\u00a020), and asymptomatic patients with pancreatic enzyme abnormalities (AP\u2010P) (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) based on the Rome IV classification and the Japan Pancreatic Association were enrolled in this study. The enrolled patients were evaluated using endoscopic ultrasonography and endoscopic ultrasonography elastography. Five pancreatic enzymes were estimated. Pancreatic exocrine function was analyzed using the BT\u2010PABA test. Lighter and heavier apoA2 isoforms, AT and ATQ levels were measured by enzyme\u2010linked immunosorbent assay methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in clinical characteristics such as age, gender, body mass index, alcohol consumption and smoking among patients with AP\u2010P, FD\u2010P, and ECP. The BT\u2010PABA test and lighter apoA2 isoform, AT level in the enrolled patients had a significant correlation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). The BT\u2010PABA test in patients with ECP was significantly lower (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) than that in AP\u2010P. ApoA2\u2010AT level in patients with ECP was lower than that in AP\u2010P, albeit, insignificantly. Interestingly, apo A2\u2010AT level was significantly (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.041) associated with exocrine pancreatic insufficiency by multiple logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ApoA2\u2010AT level is a useful tool to evaluate exocrine pancreatic insufficiency in the early stage of chronic pancreatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16302","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T06:27:32Z","timestamp":1690525652000},"page":"1949-1957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Apolipoprotein A2 isoforms associated with exocrine pancreatic insufficiency in early chronic 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