{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:24:45Z","timestamp":1777663485036,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>With changes in the epidemiology and treatment of chronic liver disease (CLD), the impact of various etiologies of liver disease on steatosis and advanced fibrosis are uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was conducted among liver disease patients of various etiologies undergoing transient elastography (TE) over a 9\u2010year duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data for 2886 patients were analyzed and had the following demographics: The median age was 60 (IQR: 45\u201369) years, 51% were males, and ethnicity was predominantly Chinese (52.5%), followed by Malays (34%) and Indians (12.3%). The median CAP score was 272 (IQR: 219\u2013319) dB\/m and the median liver stiffness measurement (LSM) score was 6.5 (IQR: 4.9\u20139.7) kPa. Hepatic steatosis occurred across the spectrum of etiologies of CLD. Among patients with steatosis, the most common etiologies were nonalcoholic fatty liver disease (NAFLD) at 62% and chronic hepatitis B (CHB) at 26.3%. TE findings suggestive of cACLD (10.1\u201315\u00a0kPa) and highly suggestive of cACLD (&gt;15\u00a0kPa) were observed in 11.3% and 12.4% of patients, respectively. NAFLD was found to be the most common etiology for cases with suggestive of cACLD (47.2%) and highly suggestive of cACLD (41.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hepatic steatosis is common in CLD, regardless of etiology. Compared with other etiologies, NAFLD is now the leading cause of cACLD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16313","type":"journal-article","created":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T21:43:52Z","timestamp":1692567832000},"page":"1818-1822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Frequency of significant steatosis and compensated advanced chronic liver disease among adults with chronic liver disease"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6892-6999","authenticated-orcid":false,"given":"Shahreedhan","family":"Shahrani","sequence":"first","affiliation":[{"name":"Department of Medicine University of Malaya Medical Centre  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep Singh","family":"Gill","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choong Yeong","family":"Sooi","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Malaya Medical Centre  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Skantha","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Malaya Medical Centre  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Vikneshwaran Chandra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Malaya Medical Centre  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Fairul","family":"Limun","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Malaya Medical Centre  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nik Arsyad Nik Muhamad","family":"Affendi","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Malaya Medical Centre  Kuala Lumpur Malaysia"},{"name":"Faculty of Medicine International Islamic University  Kuantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9811-7546","authenticated-orcid":false,"given":"Kee Huat","family":"Chuah","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Khoo","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Malaya Medical Centre  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruveena Bhavani","family":"Rajaram","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Malaya Medical Centre  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9105-5837","authenticated-orcid":false,"given":"Wah Kheong","family":"Chan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5824-0590","authenticated-orcid":false,"given":"Sanjiv","family":"Mahadeva","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"WHO:Global health estimates.2016[cited 2020 15 June]; 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