{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:00:31Z","timestamp":1785344431893,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002380","name":"Hanyang University","doi-asserted-by":"publisher","award":["HY\u2010202300000001153"],"award-info":[{"award-number":["HY\u2010202300000001153"]}],"id":[{"id":"10.13039\/501100002380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Low\u2010volume bowel preparation solutions, including 1\u2010L polyethylene glycol plus ascorbate (PEG\u2010A), have been developed to improve tolerability. The oral sodium sulfate tablet (OST) is a new agent with simethicone as a preloaded component. We investigated the efficacy, safety, and tolerability of OST compared to 1\u2010L PEG\u2010A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center, prospective, controlled study was performed with randomization into the OST (group A) and 1\u2010L PEG\u2010A (group B) groups. Bowel preparation efficacy was assessed on the Boston Bowel Preparation Scale (BBPS) and Bubble Scale. Safety and tolerability were evaluated using a questionnaire and laboratory examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Final analysis was performed on 171 patients (group A: 87, group B: 84). The proportion of bowel preparation success (BBPS\u00a0\u2265\u00a02 for each colonic segment) in group A was not inferior compared to group B (95.4% <jats:italic>vs<\/jats:italic> 96.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.736, 1\u2010sided 97.5% lower confidence limit \u22127.0%). The adenoma detection rate was not different (59.6% <jats:italic>vs<\/jats:italic> 41.9%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.087). The bubble scale was better in group A (0.2\u00a0\u00b1\u00a00.9 <jats:italic>vs<\/jats:italic> 1.9\u00a0\u00b1\u00a01.7, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). All adverse events were mild in both groups. Nausea was less frequent in group A (14.9% <jats:italic>vs<\/jats:italic> 38.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Overall satisfaction was better in group A (8.1\u00a0\u00b1\u00a02.1 <jats:italic>vs<\/jats:italic> 6.4\u00a0\u00b1\u00a02.8, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). No clinically significant laboratory abnormality developed in both groups. These findings were similarly shown in old patients \u226565\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both OST and 1\u2010L PEG\u2010A were efficacious, safe, and tolerable for bowel preparation of colonoscopy. The OST showed fewer bubbles and slightly better tolerability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16343","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T11:23:32Z","timestamp":1693567412000},"page":"2090-2096","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and safety of oral sodium sulfate tablet compared with 1\u2010L polyethylene glycol plus ascorbate: a prospective, randomized, endoscopist\u2010blinded trial"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9402-5780","authenticated-orcid":false,"given":"Jin Hwa","family":"Park","sequence":"first","affiliation":[{"name":"Department of Gastroenterology University of Hanyang College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1440-9950","authenticated-orcid":false,"given":"Seung Wook","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine, Asan Medical Center  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Wook","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine, Asan Medical Center  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5366-5749","authenticated-orcid":false,"given":"Sang Hyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine, Asan Medical Center  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Hoon","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine, Asan Medical 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