{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T12:30:58Z","timestamp":1755693058998,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The causal linkage between primary sclerosing cholangitis (PSC) and kidney function is unexplored despite their potential for long\u2010term detrimental effects on kidney function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two\u2010sample summary\u2010level Mendelian randomization (MR) study was conducted to identify the association between PSC and kidney function. The genetic variants were extracted from the PSC\u2010specific multi\u2010trait analyzed genome\u2010wide association study (GWAS) of European ancestry. Summary\u2010level data for kidney function traits, including estimated glomerular filtration rate (eGFR), annual eGFR decline, and chronic kidney disease (CKD), were obtained from the CKDGen consortium. Multiplicative random\u2010effects inverse\u2010variance weighted (MR\u2010IVW), and a series of pleiotropy\u2010robust analyses were performed to investigate the causal effects and ascertain their robustness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant causal associations between genetically predicted PSC and kidney function traits were identified. Genetically predicted PSC was associated with decreased log\u2010transformed eGFR (MR\u2010IVW; beta\u00a0=\u00a0\u22120.41%; standard error [SE]\u00a0=\u00a00.02%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), increased rate of annual eGFR decline (MR\u2010IVW; beta\u00a0=\u00a02.43%; SE\u00a0=\u00a00.18%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and higher risk of CKD (MR\u2010IVW; odds ratio\u00a0=\u00a01.07; 95% confidence interval = 1.06\u20131.08; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The main findings were supported by pleiotropy\u2010robust analysis, including MR\u2010Egger with bootstrapped error and weighted median.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrates that genetically predicted PSC is causally associated with kidney function impairment. Further studies are warranted to identify the underlying mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16355","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T03:59:35Z","timestamp":1695182375000},"page":"185-192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Primary sclerosing cholangitis causally affects kidney function decline: A Mendelian randomization study"],"prefix":"10.1111","volume":"39","author":[{"given":"Jeong Min","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hun","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Geun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Inje University Sanggye Paik Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soojin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Uijeongbu Eulji University Medical Center  Seoul South Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaerim","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Keimyung University School of Medicine  Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung\u2010Ang University Gwangmyeong Hospital  Gwangmyeong South 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