{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:22:51Z","timestamp":1779175371703,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773501"],"award-info":[{"award-number":["81773501"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073626"],"award-info":[{"award-number":["82073626"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2500405"],"award-info":[{"award-number":["2021YFC2500405"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["Z201100006820093"],"award-info":[{"award-number":["Z201100006820093"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study aimed to evaluate the impact of Lugol\u2010unstained lesion (LUL) location on the detection yield, which may help the endoscopist select targets for biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 1064 subjects who had LULs at the baseline screening of a population\u2010based randomized controlled trial. There were 1166 LULs with recorded location and pathologic diagnosis, and these were used for analysis. The detection rate of severe dysplasia and above (SDA) was calculated as the number of LULs identified as SDA divided by the number of LULs biopsied. Logistic regression with a generalized estimating equation was applied to evaluate the association between the location of a given LUL and the risk of the LUL being SDA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The detection rate of SDA for LULs located in the lower, middle, and upper esophagus increased from 5.9% and 10.9% to 16.7%. LUL location was significantly associated with having SDA (adjusted odds ratio (OR)<jats:sub>upper vs. lower<\/jats:sub>\u00a0=\u00a02.88, 95% confidential interval (CI)\u00a0=\u00a01.48\u20135.60; adjusted OR<jats:sub>middle vs. lower<\/jats:sub>\u00a0=\u00a01.63, 95% CI\u00a0=\u00a00.96\u20132.76), and the association was stronger in subgroups with a family history of esophageal squamous cell carcinoma (ESCC) (adjusted OR<jats:sub>upper vs. lower<\/jats:sub>\u00a0=\u00a09.72, 95% CI\u00a0=\u00a02.57\u201336.69; adjusted OR<jats:sub>middle vs. lower<\/jats:sub>\u00a0=\u00a03.76, 95% CI\u00a0=\u00a00.93\u201315.21).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that more attention should be paid by endoscopists to LULs in the upper and middle esophagus, particularly for individuals with a family history of ESCC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16356","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T04:49:48Z","timestamp":1695185388000},"page":"2167-2173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lugol\u2010unstained lesions location in the esophagus affects the detection rate of malignancy: a population\u2010based study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2547-6577","authenticated-orcid":false,"given":"Jing","family":"Qin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Oncology, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Genetics Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengfei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Oncology, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Genetics Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anxiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Endoscopy Center Anyang Cancer Hospital  Anyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanhai","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Oncology, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Genetics Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3774-1473","authenticated-orcid":false,"given":"Zifan","family":"Qi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Oncology, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Genetics Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Oncology, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Genetics Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology Anyang Cancer Hospital  Anyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenglei","family":"Li","sequence":"additional","affiliation":[{"name":"Hua County People's Hospital  Anyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6886-6888","authenticated-orcid":false,"given":"Liping","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Endoscopy Center Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Oncology, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Genetics Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqi","family":"Pan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Oncology, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Genetics Peking University Cancer Hospital &amp; 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