{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:02:57Z","timestamp":1783612977350,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The liver plays a critical role in metabolic homeostasis, and its health is often compromised by poor dietary habits. This study aimed to investigate the therapeutic potential of SCD Probiotics in mitigating adverse liver effects induced by a cafeteria diet in male Wistar rats during their developmental period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four groups of seven male Wistar rats each were subjected to different dietary regimens from day 21 (weaning) to day 56. The groups were as follows: a control group on normal feed; a probiotic\u2010supplemented group on normal feed; a group on a cafeteria diet mixed with normal feed; and a group on a cafeteria diet mixed with normal feed, supplemented with SCD Probiotics. Liver health was assessed using Fourier transform infrared spectroscopy and histopathological evaluations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rats on the cafeteria diet exhibited significant disruptions in lipid, protein, cholesterol, triglyceride levels, and glycogen\/phosphate content. Histopathological abnormalities such as lymphocytic infiltration, steatosis, and necrosis were also observed. However, SCD Probiotics supplementation led to notable improvements in the liver's biomolecular composition and mitigated histopathological abnormalities. Serum liver enzyme levels (AST, ALT, ALP, and LDH) also showed beneficial effects, while serum albumin levels remained stable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SCD Probiotics demonstrated a promising potential to counteract the adverse liver effects induced by a cafeteria diet in male Wistar rats. The study revealed significant improvements in biomolecular composition, histopathology, and serum enzyme levels. However, these findings are preliminary and necessitate further in vivo studies and clinical trials for validation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16395","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T23:45:26Z","timestamp":1700005526000},"page":"2142-2151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["SCD Probiotics mitigate cafeteria diet\u2010induced liver damage in Wistar rats during development"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3041-6010","authenticated-orcid":false,"given":"Taha","family":"Ceylani","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics Mu\u015f Alparslan University  Mu\u015f Turkey"},{"name":"Department of Food Quality Control and Analysis Mu\u015f Alparslan University  Mu\u015f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harun","family":"\u00d6nl\u00fc","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Mu\u015f Alparslan University  Mu\u015f Turkey"},{"name":"Department of Food Quality Control and Analysis Mu\u015f Alparslan University  Mu\u015f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda","family":"Keskin","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Van Yuzuncu Yil University  Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"Allahverdi","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Mu\u015f Alparslan University  Mu\u015f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6621-3071","authenticated-orcid":false,"given":"Hikmet Taner","family":"Teker","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics Ankara Medipol University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"ZenardiniB AmirM SilveiraD SagaeSC PaulaL.Cafeteria Diet And Obesity: Mutagenicity in Wistar rats and consequences on female offspring.2017;07(Popkin 2006):16016\u20139."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111571"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2013-0410"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.6656"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00078.2006"},{"key":"e_1_2_6_7_1","first-page":"1","article-title":"Impact of maternal obesity on liver disease in the offspring: a comprehensive transcriptomic analysis and confirmation of results in a murine model","volume":"10","author":"Moeckli B","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01159"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-022-00286-w"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-022-03154-8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10123\u2010022\u201000272\u20107"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2023.105003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15713"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080169"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2015.39.4.291"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113138"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.110"},{"key":"e_1_2_6_18_1","first-page":"421","volume-title":"Vibrational spectroscopy in diagnosis and screening","author":"Severcan F","year":"2012"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166799"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2022.166473"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522\u2010023\u201010032\u20103"},{"key":"e_1_2_6_22_1","first-page":"1","article-title":"The rejuvenating influence of young plasma on aged intestine","author":"Ceylani T","year":"2023","journal-title":"J. Cell. Mol. Med."},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.7.1678"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/902917"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.18"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059470"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8070415"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-019-9021-y"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21381"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284\u2010022\u201002783\u2010y"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.05.023"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111571"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2023.112019"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202200479"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2009.04.012"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112482"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-97487-x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.01.002"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01809"},{"key":"e_1_2_6_40_1","first-page":"11","article-title":"Effects of Lactobacillus acidophilus on biochemical indices and liver histology in streptozotocin\u2010induced diabetic rats","author":"Adesiji Y","year":"2019","journal-title":"J. Clin. Diagn. Res."},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2021.110490"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.38"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011171"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1142527"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.16395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T05:56:10Z","timestamp":1744264570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.16395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,14]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/jgh.16395"],"URL":"https:\/\/doi.org\/10.1111\/jgh.16395","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,14]]},"assertion":[{"value":"2023-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}