{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:05:55Z","timestamp":1792181155655,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastric cancer (GC) is a common malignancy with high incidence and mortality, and its pathogenesis involves the regulation of circular RNAs (circRNAs). However, the molecular mechanism of circTMEM87A in GC malignant progression is uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Quantitative real\u2010time polymerase chain reaction (qRT\u2010PCR) was performed to detect the expressions of circTMEM87A, miR\u20101276, and solute carrier family 7 membrane 11 (SLC7A11). Western blot was applied to detect protein expression levels of EMT\u2010related proteins (vimentin and E\u2010cadherin) and SLC7A11. Cell counting kit\u20108 assay (CCK8) and thymidine analog 5\u2010ethynyl\u20102\u2032\u2010deoxyuridine (EdU) were performed to assess cell proliferation. Apoptosis was investigated using flow cytometry. Transwell assay and wound healing assay were carried out to examine the migration of MKN\u20107 and AGS cells. The Cellular ROS Assay Kit, Iron Assay Kit, and GSH\/GSSG Ratio Detection Assay Kit were utilized to monitor lipid ROS level, iron level, and GSH\/GSSG ratio, respectively. The interaction between miR\u20101276 and circTMEM87A or SLC7A11 was investigated using dual\u2010luciferase reporter assay and RNA immunoprecipitation (RIP) assay. A xenograft mouse model was constructed to explore the function of circTMEM87A in tumor formation in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CircTMEM87A and SLC7A11 were upregulated, while miR\u20101276 was downregulated in GC tissues and cells. Knockdown of circTMEM87A suppressed the proliferation and migration and promoted apoptosis and ferroptosis of GC cells. CircTMEM87A served as a sponge for miR\u20101276, and miR\u20101276 inhibitor relieved the circTMEM87A knockdown\u2010induced effects on GC cell phenotypes. Similarly, SLC7A11, a downstream gene of miR\u20101276, rescued miR\u20101276 overexpression\u2010induced effects on GC cell function. Furthermore, circTMEM87A knockdown inhibited GC cell tumor phenotypes in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CircTMEM87A promoted the proliferation and migration and inhibited apoptosis and ferroptosis of GC cells by increasing SLC7A11 expression through binding to miR\u20101276.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16402","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T07:25:53Z","timestamp":1701415553000},"page":"121-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["CircTMEM87A promotes the tumorigenesis of gastric cancer by regulating the miR\u20101276\/SLC7A11 axis"],"prefix":"10.1111","volume":"39","author":[{"given":"Xueguang","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Jinan People's Hospital Affiliated to Shandong First Medical University  Jinan 271100 Shandong 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