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We aimed to characterize the clinicopathologic characteristics, feasibility, and safety of ER for JILs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively investigated 52 patients with JILs who underwent ER from January 2012 to February 2022. We collected and analyzed clinicopathological characteristics, procedure\u2010related parameters, outcomes, and follow\u2010up data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 49.4\u00a0years. Of the 52 JILs, 33 ileal tumors within 20\u00a0cm from the ileocecal valve were resected with colonoscopy, while 19 tumors in the jejunum or the ileum over 20\u00a0cm from the ileocecal valve received enteroscopy resection. The mean procedure duration was 49.0\u00a0min. The en bloc resection and en bloc with R0 resection rates were 86.5% and 84.6%, respectively. Adverse events (AEs) included one (1.9%) major AE (delayed bleeding) and five (9.6%) minor AEs. During a median follow\u2010up of 36.5\u00a0months, two patients had local recurrence (3.8%), while none had metastases. The 5\u2010year recurrence\u2010free survival (RFS) and disease\u2010specific survival (DSS) were 92.9% and 94.1%, respectively. Compared with the enteroscopy group, overall AEs were significantly lower in the colonoscopy group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), but no statistical differences were observed in RFS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.412) and DSS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.579). There were no significant differences in AEs, RFS, and DSS between the endoscopic submucosal dissection (ESD) and the endoscopic mucosal resection (EMR) group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ER of JILs has favorable short\u2010term and long\u2010term outcomes. Both ESD and EMR can safely and effectively resect JILs in appropriately selected cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16413","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T08:35:14Z","timestamp":1700210114000},"page":"527-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Feasibility and safety of endoscopic resection for the jejunoileal lesions"],"prefix":"10.1111","volume":"39","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Shanghai Collaborative Innovation Center of Endoscopy  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu\u2010Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute Zhongshan Hospital, Fudan 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