{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:30:21Z","timestamp":1747186221054,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH\u20101127303C"],"award-info":[{"award-number":["TCVGH\u20101127303C"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>A large genetic effect of a novel gallstone\u2010associated genetic variant, the hepatocyte nuclear factor 4\u03b1 (<jats:italic>HNF4A<\/jats:italic>) rs1800961 polymorphism, has been identified through recent genome\u2010wide association studies. However, this effect has not been validated in Asian populations. We investigated the association between the rs1800961 variant and gallstones among a Taiwanese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 20\u00a0405 participants aged between 30 and 70\u00a0years voluntarily enrolled in the Taiwan Biobank. Self\u2010report questionnaires, physical examinations, biochemical tests, and genotyping were used for analysis. The association of the <jats:italic>HNF4A<\/jats:italic> rs1800961 variant and other metabolic risks with gallstone disease was analyzed using multiple logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The minor T allele of <jats:italic>HNF4A<\/jats:italic> rs1800961 was associated with an increased risk of gallstone, and the association remained significant even after adjustment for other risk factors including age, body mass index (BMI), diabetes, hyperlipidemia, hypertension, and cigarette smoking (adjusted odds ratio [OR]\u00a0=\u00a01.90, 95% confidence interval [CI]\u00a0=\u00a01.31 to 2.75) in male participants. When further stratified by BMI and age, the lithogenic effect was the most significant in male participants with obesity (adjusted OR\u00a0=\u00a03.55, 95% CI\u00a0=\u00a01.92 to 6.56) and who were younger (adjusted OR\u00a0=\u00a02.45, 95% CI\u00a0=\u00a01.49 to 4.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The novel gallstone\u2010associated <jats:italic>HNF4A<\/jats:italic> rs1800961 variant was associated with the risk of gallstone in the Taiwanese men. Screening for the rs1800961 polymorphism may be particularly useful in assessing the risk of gallstone formation in younger or obese men.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16426","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T23:15:18Z","timestamp":1701990918000},"page":"305-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between <i>HNF4A<\/i> rs1800961 polymorphisms and gallstones in a Taiwanese population"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7665-0988","authenticated-orcid":false,"given":"Ying\u2010Cheng","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u2010Chieh","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Research Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen\u2010Ju","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Research Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Tsai","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jui\u2010Chun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Women's Health Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsai\u2010Jung","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Division of Nephrology, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Critical Care Medicine Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Research Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"},{"name":"Precision Medicine Research Center, College of Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Heng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Research Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Public Health, College of Medicine Fu Jen Catholic University  New Taipei City Taiwan"},{"name":"Department of Industrial Engineering and Enterprise Information Tunghai University  Taichung Taiwan"},{"name":"Institute of Public Health and Community Medicine Research Center National Yang Ming Chiao Tung University  Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2006.05.004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296436"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.24"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.08.045"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SGA.0000000000000235"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20654"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2101"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12935"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30313"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07460-y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32199"},{"key":"e_1_2_7_13_1","unstructured":"Taiwan Biobank. 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