{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:56:46Z","timestamp":1776704206173,"version":"3.51.2"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>While European Society of Pediatric Gastroenterology Hepatology and Nutrition advocates a no\u2010biopsy pathway for the diagnosis of celiac disease (CeD) in children if IgA anti\u2010tissue transglutaminase antibody (anti\u2010tTG ab) titer is \u226510\u2010fold upper limit of normal (ULN) and have a positive IgA anti\u2010endomysial antibody (EMA); the data for anti\u2010tTG Ab titer\u2010based diagnosis of CeD in adults is still emerging. We planned to validate if IgA anti\u2010tTG Ab titer \u226510\u2010fold predicts villous abnormalities of modified Marsh grade \u22652 in Asian adult patients with CeD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 937 adult patients with positive anti\u2010tTG Ab from two databases, including AIIMS Celiac Clinic and Indian National Biorepository. The diagnosis of definite CeD was made on the basis of a positive anti\u2010tTG Ab and the presence of villous abnormalities of modified Marsh grade \u22652.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 937 adult patients with positive anti\u2010tTG Ab, 889 (91.2%) showed villous abnormalities of modified Marsh grade \u22652. Only 47.6% of 889 adults with CeD had anti\u2010 tTG Ab titers of \u226510\u2010fold. The positive predictive value (PPV) and specificity of anti tTG Ab titer \u226510\u2010fold for predicting modified Marsh grade \u22652 were 99.8% and 98%, respectively. At anti\u2010tTG Ab titer \u226511\u2010fold, specificity and PPV were 100% for predicting villous abnormalities of modified Marsh grade \u22652.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Approximately 50% of adults with CeD may benefit from the no biopsy pathway, reducing the health burden and risks of gastroscopy\/anesthesia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16436","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T12:11:59Z","timestamp":1702555919000},"page":"489-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Validation of no\u2010biopsy pathway for the diagnosis of celiac disease in Asian adults: a multicenter retrospective study"],"prefix":"10.1111","volume":"39","author":[{"given":"Aditya Vikram","family":"Pachisia","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Human Nutrition Unit All India 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Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Post graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8088-9935","authenticated-orcid":false,"given":"Saroj Kant","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Post graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medicine Sardar Patel Medical College  Bikaner"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahender","family":"Rajput","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Human 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