{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:30:22Z","timestamp":1747186222921,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Potassium\u2010competitive acid blockers more strongly suppress the gastric acid barrier than proton pump inhibitors and cause dysbiosis. However, preventive measures in this regard have not been established. We aimed to evaluate whether 1\u2010kestose, a known prebiotic, was effective at alleviating dysbiosis caused by potassium\u2010competitive acid blockers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients scheduled to undergo endoscopic resection for superficial gastroduodenal tumors were enrolled and randomized 1:1 to receive either 1\u2010kestose or placebo. All patients were started on potassium\u2010competitive acid blocker (vonoprazan 20\u00a0mg\/day) and took 1\u2010kestose 10\u00a0g\/day or placebo (maltose) 5\u00a0g\/day for 8\u00a0weeks. The primary outcome was the effect of 1\u2010kestose on potassium\u2010competitive acid blocker\u2010induced alterations in the microbiome. The fecal microbiome was analyzed before and after potassium\u2010competitive acid blocker treatment via MiSeq (16S rRNA gene V3\u2013V4 region).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty patients were enrolled, and 16 in each group were analyzed. In the placebo group, the Simpson index, an alpha diversity, was significantly decreased and relative abundance of <jats:italic>Streptococcus<\/jats:italic> was significantly increased by 1.9\u2010fold. In the kestose group, the Simpson index did not change significantly and relative abundance of <jats:italic>Streptococcus<\/jats:italic> increased 1.3\u2010fold, but this was not a significant change. In both groups, no adverse events occurred, ulcers were well healed, and pretreatment and posttreatment short\u2010chain fatty acid levels did not differ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The potassium\u2010competitive acid blocker caused dysbiosis in the placebo group; this effect was prevented by 1\u2010kestose. Thus, 1\u2010kestose may be useful in dysbiosis treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16445","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T08:29:45Z","timestamp":1703665785000},"page":"480-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of 1\u2010kestose on microbiome changes caused by vonoprazan: a randomized, double\u2010blind, placebo\u2010controlled pilot study"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-3996","authenticated-orcid":false,"given":"Satoshi","family":"Furune","sequence":"first","affiliation":[{"name":"Department of Clinical Oncology and Chemotherapy Nagoya University Hospital  Nagoya Japan"},{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8951-0952","authenticated-orcid":false,"given":"Takashi","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0980-9095","authenticated-orcid":false,"given":"Kazuhiro","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5444-143X","authenticated-orcid":false,"given":"Masanao","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0938-631X","authenticated-orcid":false,"given":"Masatoshi","family":"Ishigami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumie","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Statistical Analysis Section, Center for Advanced Medicine and Clinical Research Nagoya University Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Kadota","sequence":"additional","affiliation":[{"name":"B Food Science Co., Ltd.  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