{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:09:31Z","timestamp":1777860571159,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Although age at disease onset is considered to be a significant factor in the prognosis of Crohn's disease, little is known about its influence on the long\u2010term prognosis of those with intestinal Beh\u00e7et's disease (BD). This study aimed to evaluate the long\u2010term clinical outcomes of patients with intestinal BD according to age of disease onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with intestinal BD at &lt;\u00a018, 18\u201360, and &gt;\u00a060\u00a0years of age were classified into early\u2010onset, adult\u2010onset, and late\u2010onset groups, respectively. The influence of disease onset time on clinical prognosis, including specific medical requirements, BD\u2010related intestinal surgery, hospitalization, and emergency room visits, was compared using the log\u2013rank test in a large cohort of patients with intestinal BD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 780 patients, 21 (2.7%), 672 (86.2%), and 87 (11.1%) comprised the early\u2010onset, adult\u2010onset, and late\u2010onset groups, respectively. Patients in the early\u2010onset group were more likely to require immunosuppressants than those in the adult\u2010onset group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.048). Nine (42.9%), 158 (23.5%), and 18 (20.7%) patients in the early\u2010onset, adult\u2010onset, and late\u2010onset groups, respectively, underwent intestinal resection. The early\u2010onset group exhibited a higher risk for intestinal resection than the late\u2010onset (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.043) and adult\u2010onset (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.030) groups. The late\u2010onset group exhibited a higher risk for BD\u2010related hospitalization than the adult\u2010onset group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Age at diagnosis affected the clinical course of intestinal BD, including intestinal surgery, hospitalization, and specific medical requirements. Different treatment strategies should be established according to age at diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16449","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T09:15:05Z","timestamp":1703668505000},"page":"519-526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of age at diagnosis on long\u2010term prognosis in patients with intestinal Beh\u00e7et's disease"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7951-456X","authenticated-orcid":false,"given":"Ji Young","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Health Promotion Medicine Ewha Womans University Seoul Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0699-6809","authenticated-orcid":false,"given":"Soo Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul South Korea"},{"name":"Institute of Gastroenterology Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"},{"name":"Inflammatory Bowel Disease Center Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9974-1658","authenticated-orcid":false,"given":"Jae Jun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul South Korea"},{"name":"Institute of Gastroenterology Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"},{"name":"Inflammatory Bowel Disease Center Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4807-890X","authenticated-orcid":false,"given":"Tae Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul South Korea"},{"name":"Institute of Gastroenterology Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"},{"name":"Inflammatory Bowel Disease Center Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2282-8904","authenticated-orcid":false,"given":"Jae Hee","family":"Cheon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul South Korea"},{"name":"Institute of Gastroenterology Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"},{"name":"Inflammatory Bowel Disease Center Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"},{"name":"Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5836-8735","authenticated-orcid":false,"given":"Jihye","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul South Korea"},{"name":"Institute of Gastroenterology Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"},{"name":"Inflammatory Bowel Disease Center Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848231167283"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4078\/jrd.2021.28.1.4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2351-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1300-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000125"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2016.57.1.22"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw116"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.127"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy168"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jju016"},{"key":"e_1_2_7_12_1","first-page":"445","article-title":"Development and validation of risk matrices for Crohn's disease outcomes in patients who underwent early therapeutic interventions","volume":"11","author":"Dias CC","year":"2017","journal-title":"J Crohns Colitis"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.019"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520801957149"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.09.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2015.13.1.60"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000309"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21119"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2021.00142"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000442921.77945.09"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000465"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.331"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2021.00177"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619860661"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12107"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21313"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200108000-00010"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21833"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16056"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2022.0264"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9012"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2021.00139"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2022.00135"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2017.15.3.318"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2017.377"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21757"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3799-1"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03555.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2104"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2471"},{"key":"e_1_2_7_41_1","first-page":"S6","article-title":"Beh\u00e7et's disease: an update on the pathogenesis","volume":"19","author":"G\u00fcl A","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_42_1","first-page":"3","article-title":"Pathogenesis and treatment of intestinal Beh\u00e7et's disease","volume":"50","author":"Lee CK","year":"2007","journal-title":"Korean J Gastroenterol"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0872-4"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2022.00007"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2022.00029"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2021.00018"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2021.00037"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2013.54.5.1084"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2019.10.003"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.07.023"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.16449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T05:39:29Z","timestamp":1744263569000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.16449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,27]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/jgh.16449"],"URL":"https:\/\/doi.org\/10.1111\/jgh.16449","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,27]]},"assertion":[{"value":"2023-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}