{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:42:34Z","timestamp":1789756954980,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>More insight into the incidence of and factors associated with progression following a first episode of acute pancreatitis (AP) would offer opportunities for improvements in disease management and patient counseling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A long\u2010term post hoc analysis of a prospective cohort of patients with AP (2008\u20132015) was performed. Primary endpoints were recurrent acute pancreatitis (RAP), chronic pancreatitis (CP), and pancreatic cancer. Cumulative incidence calculations and risk analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 1184 patients with a median follow\u2010up of 9\u00a0years (IQR: 7\u201311) were included. RAP and CP occurred in 301 patients (25%) and 72 patients (6%), with the highest incidences observed for alcoholic pancreatitis (40% and 22%). Pancreatic cancer was diagnosed in 14 patients (1%). Predictive factors for RAP were alcoholic and idiopathic pancreatitis (OR 2.70, 95% CI 1.51\u20134.82 and OR 2.06, 95% CI 1.40\u20133.02), and no pancreatic interventions (OR 1.82, 95% CI 1.10\u20133.01). Non\u2010biliary etiology (<jats:italic>alcohol<\/jats:italic>: OR 5.24, 95% CI 1.94\u201314.16, <jats:italic>idiopathic<\/jats:italic>: OR 4.57, 95% CI 2.05\u201310.16, and <jats:italic>other<\/jats:italic>: OR 2.97, 95% CI 1.11\u20137.94), RAP (OR 4.93, 95% CI 2.84\u20138.58), prior pancreatic interventions (OR 3.10, 95% CI 1.20\u20138.02), smoking (OR 2.33, 95% CI 1.14\u20134.78), and male sex (OR 2.06, 95% CI 1.05\u20134.05) were independently associated with CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Disease progression was observed in a quarter of pancreatitis patients. We identified several risk factors that may be helpful to devise personalized strategies with the intention to reduce the impact of disease progression in patients with AP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16453","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T01:34:12Z","timestamp":1704764052000},"page":"674-684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Development of pancreatic diseases during long\u2010term follow\u2010up after acute pancreatitis: a post\u2010hoc analysis of a prospective multicenter cohort"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5315-2230","authenticated-orcid":false,"given":"FEM","family":"de Rijk","sequence":"first","affiliation":[{"name":"Department of Research and Development St. Antonius Hospital  Nieuwegein The Netherlands"},{"name":"Department of Gastroenterology and Hepatology Erasmus 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Gastroenterology Endocrinology Metabolism  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ND","family":"Hallensleben","sequence":"additional","affiliation":[{"name":"Department of Research and Development St. Antonius Hospital  Nieuwegein The Netherlands"},{"name":"Department of Gastroenterology and Hepatology Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MPGF","family":"Anten","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Sint Franciscus Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Brink","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Meander Medical Center  Amersfoort The 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