{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:50:19Z","timestamp":1782802219617,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T00:00:00Z","timestamp":1704585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["T32DK007634\u201034"],"award-info":[{"award-number":["T32DK007634\u201034"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Food\/environmental allergens have been associated with eosinophilic esophagitis (EoE); however, the correlation between allergy profiles and disease responsiveness to proton pump inhibitor (PPI) therapy remains unclear. We aimed to assess the association between food\/environmental allergies identified on allergen testing and histologic response to PPI in patients with treatment\u2010naive EoE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults with newly diagnosed EoE who underwent formal testing for food\/environmental allergies at a tertiary center were included. All patients underwent twice\u2010daily PPI for 8\u00a0weeks with subsequent repeat endoscopy and biopsy to assess histologic response. Patients with &lt;15 eosinophils\/hpf on post\u2010PPI mucosal biopsies were classified as responders (PPI\u2010r\u2010EoE), while those with \u226515 eosinophils\/hpf were nonresponders (PPI\u2010nr\u2010EoE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one patients met inclusion criteria (21 PPI\u2010r\u2010EoE <jats:italic>vs<\/jats:italic> 40 PPI\u2010nr\u2010EoE). Demographic, clinical, and endoscopic finding variables were similar between groups. Positive food allergen test was more prevalent among PPI\u2010nr\u2010EoE patients (82.5% <jats:italic>vs<\/jats:italic> 42.9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). On multivariable analysis, positive food allergen testing remained an independent predictor for PPI nonresponse (aOR 0.15, CI: 0.04\u20130.58, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0006). Positive environmental allergen testing was highly prevalent, with no significant differences between groups (77.5% <jats:italic>vs<\/jats:italic> 95.2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.14). However, higher number of positive environmental allergens (23.3% [\u22655 allergens] <jats:italic>vs<\/jats:italic> 73.3% [&lt;5 allergens], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) and specific aeroallergens correlated with PPI\u2010nr\u2010EoE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Positive food allergy testing and increased environmental allergens predicted lower likelihood of histologic response to PPI in EoE. Our findings support an allergic phenotype of EoE that may less likely respond to PPI therapy. Formal allergen testing may play a role in therapy selection and tailored management in EoE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16469","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T04:19:40Z","timestamp":1704687580000},"page":"701-707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Allergic phenotype identified on allergen testing is associated with proton pump inhibitor nonresponse in eosinophilic esophagitis"],"prefix":"10.1111","volume":"39","author":[{"given":"Mayssan","family":"Muftah","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Endoscopy Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Medicine Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davis A.","family":"Hartnett","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Medicine Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Endoscopy Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Medicine Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walker D.","family":"Redd","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of North Carolina Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Endoscopy Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Medicine Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison H.","family":"Goldin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Endoscopy Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Medicine Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Hsu Blatman","sequence":"additional","affiliation":[{"name":"Section of Allergy and Clinical Immunology Dartmouth 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