{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:40:27Z","timestamp":1789000827593,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004470","name":"Daewoong Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004470","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Fexuprazan is a novel potassium\u2010competitive acid blocker (P\u2010CAB). This study aimed to explore the noninferior efficacy and safety of fexuprazan to esomeprazole in treating erosive esophagitis (EE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a phase III, randomized, double\u2010blind multicenter study. Patients with endoscopically confirmed EE were randomized to receive fexuprazan 40\u00a0mg or esomeprazole 40\u00a0mg once a daily for 4\u20138\u00a0weeks. The healing rates of EE, symptom response, GERD\u2010health\u2010related quality life (GERD\u2010HRQL), and treatment\u2010emergent adverse events (TEAEs) were compared between fexuprazan group and esomeprazole group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 332 subjects were included in full analysis set (FAS) and 311 in per\u2010protocol set (PPS). The healing rates of fexuprazan and esomeprazole groups at 8\u00a0weeks were 88.5% (146\/165) and 89.0% (145\/163), respectively, in FAS and 97.3% (145\/149) and 97.9% (143\/146), respectively, in PPS. Noninferiority of fexuprazan compared with esomeprazole according to EE healing rates at 8\u00a0weeks was demonstrated in both FAS and PPS analysis. No significant difference was found between groups in EE healing rates at 4\u00a0weeks, symptom responses, and changes of GERD\u2010HRQL. The incidence of drug\u2010related AEs was 19.4% (32\/165) in fexuprazan arm and 19.6% (32\/163) in esomeprazole arm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated noninferior efficacy of fexuprazan to esomeprazole in treating EE. The incidence of TEAEs was similar between fexuprazan and esomeprazole.<\/jats:p><jats:p>Trial registration number NCT05813561.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16471","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T12:23:05Z","timestamp":1705926185000},"page":"658-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The efficacy and safety of fexuprazan in treating erosive esophagitis: a phase III, randomized, double\u2010blind, multicenter study"],"prefix":"10.1111","volume":"39","author":[{"given":"Qianjun","family":"Zhuang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First 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