{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:16:01Z","timestamp":1793646961125,"version":"4.5.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Up to 40% of gastroesophageal reflux disease (GERD) patients experience inadequate symptom relief with a proton pump inhibitor (PPI), termed PPI\u2010resistant or refractory GERD. Vonoprazan, a potassium\u2010competitive acid blocker, has better efficacy than PPI in suppressing gastric acid secretion. This meta\u2010analysis summarizes the efficacy and safety of vonoprazan for treating PPI\u2010resistant GERD (both erosive esophagitis [EE] and non\u2010erosive reflux disease [NERD]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four electronic databases (Medline, Embase, SCOPUS, and CENTRAL) were searched for studies indexed until August 1, 2023. Both observational studies and clinical trials assessing the efficacy and safety of vonoprazan in PPI\u2010resistant GERD were included. Efficacy outcomes included healing and maintenance rates of EE and improvement of the Frequency Scale for Symptoms of GERD (FSSG) scores. Serious adverse events (SAEs) were considered a safety outcome. The modified Newcastle\u2010Ottawa Scale (NOS) was used to assess study quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve studies were included in this meta\u2010analysis. Healing rates of PPI\u2010resistant EE with vonoprazan 20\u00a0mg were 91.7% (95% CI 86.8\u201394.8%) and 88.5% (95% CI 69.7\u201396.2%) at weeks 4 and 8, respectively. For healed PPI\u2010resistant EE, the overall maintenance rates with vonoprazan 10\u00a0mg were 82.6% (95% 61.2\u201395.0%) at week 8, 86.0% (95% CI 72.1\u201394.7%) at week 24, and 93.8% (95% CI 69.8\u201399.8%) at week 48. FSSG scores were improved in 74.6% (95% CI 65.8\u201381.7%) and 51.9% (95% CI 37.8\u201365.7%) of patients at weeks 4 and 8. Overall, no SAE was reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vonoprazan demonstrated high efficacy in the healing and maintenance of PPI\u2010resistant EE and moderate efficacy for the improvement of FSSG score. Vonoprazan was well tolerated in PPI\u2010resistant GERD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16475","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T21:33:29Z","timestamp":1706045609000},"page":"796-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A systematic review and meta\u2010analysis of the efficacy of vonoprazan for proton pump inhibitor\u2010resistant gastroesophageal reflux disease"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7512-2112","authenticated-orcid":false,"given":"Daniel Martin","family":"Simadibrata","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester MN USA"},{"name":"Nuffield Department of Population Health University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Lesmana","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester MN USA"},{"name":"Faculty of Medicine Universitas Indonesia  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie","family":"Fass","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, MetroHealth Medical System Case Western Reserve University  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2114026"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2018.08.002"},{"key":"e_1_2_7_5_1","first-page":"196","article-title":"Treatment of refractory gastroesophageal reflux disease","volume":"16","author":"Naik RD","year":"2020","journal-title":"Gastroenterol. 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