{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:51:38Z","timestamp":1791204698386,"version":"4.2.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Clinical data on the association between leptin levels and nonalcoholic fatty liver disease (NAFLD)\u2010related liver fibrosis are conflicting. This meta\u2010analysis aimed to compare circulating leptin between NAFLD patients with versus without liver fibrosis or non\u2010NAFLD controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was conducted in PubMed, Scopus, and the Cochrane Library. Fifteen studies were included, reporting data from 964 individuals (422 NAFLD patients with fibrosis, 297 NAFLD patients without fibrosis, 245 no\u2010NAFLD controls).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Leptin standardized mean difference (SMD) was higher in NAFLD patients with fibrosis (F1\u2013F4) than in controls (SMD: 2.27; 95% confidence interval [CI]: 0.81\u20133.73); however, this association did not remain robust after the exclusion of studies with morbidly obese individuals. No difference was observed in leptin SMD between NAFLD patients with fibrosis and those without fibrosis (F0), and NAFLD patients without fibrosis versus controls. Heterogeneity was high (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      : 66\u201398%) among studies. Meta\u2010regression analysis revealed a positive association of leptin SMD with homeostasis model assessment\u2010insulin resistance, when comparing NAFLD patients with fibrosis versus NAFLD patients without fibrosis (beta: 0.53; 95% CI: 0.04\u20131.03), and a negative association of leptin SMD with age, when comparing NAFLD patients with fibrosis versus controls (beta: \u22120.29; 95% CI: \u22120.53 to \u22120.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Circulating leptin was higher in NAFLD patients with liver fibrosis than non\u2010NAFLD controls, an association, however, attenuated after the exclusion of a study with morbidly obese individuals. Circulating leptin was not different between NAFLD patients with and without fibrosis, or NAFLD patients without fibrosis and controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16480","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T21:32:30Z","timestamp":1705613550000},"page":"806-817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Circulating leptin in patients with nonalcoholic fatty liver disease\u2010related liver fibrosis: a systematic review and a meta\u2010analysis"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3177-2129","authenticated-orcid":false,"given":"Evangelia S.","family":"Makri","sequence":"first","affiliation":[{"name":"First Laboratory of Pharmacology, School of Medicine Aristotle University of Thessaloniki  Thessaloniki 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