{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:51:35Z","timestamp":1791204695073,"version":"4.2.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>While several predictive models for the development of hepatocellular carcinoma (HCC) have been proposed, including those for patients with chronic hepatitis C virus (HCV) infection who have achieved sustained virologic response (SVR), the best model may differ between regions. We compared the ability of six reported models to stratify the risk of post\u2010SVR HCC in Japan, where rigorous surveillance and early detection of HCC is common.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 6048 patients with no history of HCC who achieved SVR by oral direct\u2010acting antiviral drugs were enrolled in this nationwide study. Patients continued HCC surveillance every 6\u00a0months after SVR. The incidence of post\u2010SVR HCC was compared between risk groups using the aMAP score, FIB\u20104 index, Tahata model, GAF4 criteria, GES score, and ADRES score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the observation period with a median duration of 4.0\u00a0years after SVR, post\u2010SVR HCC developed in 332 patients (5.5%). All six models performed significantly at stratifying the incidence of HCC. However, Harrell's C\u2010index was below 0.8 for all models (range, 0.660\u20130.748), indicating insufficient stratification ability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although all six proposed models demonstrated a good ability to predict the development of post\u2010SVR HCC, their ability to stratify the risk of post\u2010SVRHCC was unsatisfactory. Further studies are necessary to identify the best model for assessing the risk of post\u2010SVR HCC in regions where early detection of HCC is common.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16494","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:55:46Z","timestamp":1706662546000},"page":"949-954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of six hepatocellular carcinoma prediction models in Japanese patients after sustained virologic response undergoing rigorous surveillance for hepatocellular carcinoma"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-6168","authenticated-orcid":false,"given":"Hidenori","family":"Toyoda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Ogaki Municipal Hospital  Ogaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-6761","authenticated-orcid":false,"given":"Toshifumi","family":"Tada","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Japanese Red Cross Himeji Hospital  Himeji Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1719-1352","authenticated-orcid":false,"given":"Haruki","family":"Uojima","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2269-101X","authenticated-orcid":false,"given":"Akito","family":"Nozaki","sequence":"additional","affiliation":[{"name":"Gastroenterology Center Yokohama City University Medical Center  Yokohama 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Gastroenterology, Clinical Research Institute National Hospital Organization Kyushu Medical Center  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiko","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology Teine Keijinkai Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Mikami","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kikkoman General Hospital  Noda Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5470-9694","authenticated-orcid":false,"given":"Toru","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Hepatology Saiseikai Niigata Hospital  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ogaki Municipal Hospital  Ogaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Tsutsui","sequence":"additional","affiliation":[{"name":"Department of Hepatology Kagawa Prefectural Central Hospital  Takamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeang","family":"Arai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-495X","authenticated-orcid":false,"given":"Takashi","family":"Kumada","sequence":"additional","affiliation":[{"name":"Department of Nursing Gifu Kyoritsu University  Ogaki 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