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Given that appendectomy remains one of the most commonly performed operations and a first\u2010line management strategy of acute appendicitis, it is inherently crucial to elucidate the association between prior appendectomy and subsequent development of CRC, as there may be long\u2010term health repercussions. In this review, we summarize the data behind the relationship of CRC in post\u2010appendectomy patients, discuss the role of the microbiome in relation to appendectomy and CRC pathogenesis, and provide an appraisal of our current understanding of the function of the appendix. We seek to piece together the current landscape surrounding the microbiome and immunological changes in the colon post\u2010appendectomy and suggest a direction for future research involving molecular, transcriptomic, and immunologic analysis to complement our current understanding of the alterations in gut microbiome.<\/jats:p>","DOI":"10.1111\/jgh.16497","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T23:53:53Z","timestamp":1706831633000},"page":"826-835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Beyond a vestigial organ: effects of the appendix on gut microbiome and colorectal cancer"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2771-4826","authenticated-orcid":false,"given":"Daniel Ren Yi","family":"Yap","sequence":"first","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1277-9595","authenticated-orcid":false,"given":"Rashid N","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, Institute of Digestive Disease, Faculty of Medicine, State Key Laboratory of Digestive Disease The Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Department of Clinical Oncology, Faculty of Medicine the Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Samol","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore Singapore"},{"name":"Department of Medical Oncology, Tan Tock Seng Hospital National Healthcare Group  Singapore Singapore"},{"name":"Johns Hospital University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Ngeow","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore Singapore"},{"name":"National Cancer Centre Singapore Singapore Health Services  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3125-5199","authenticated-orcid":false,"given":"Joseph JY","family":"Sung","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore Singapore"},{"name":"Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital National Healthcare Group  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3354-9310","authenticated-orcid":false,"given":"Sunny H","family":"Wong","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore Singapore"},{"name":"Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital National Healthcare Group  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/18735592MTEx9NTk2y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007133430201"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9329"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00275-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000544304.30954.40"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-021-03886-x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118411"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02569-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3961\/jpmph.18.105"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151262"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.102991"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12265"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2022.102120"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.6.1343"},{"key":"e_1_2_7_16_1","article-title":"Risk of colorectal cancer after appendectomy: a systematic review and meta\u2010analysis","author":"Liu Z","year":"2023","journal-title":"J. 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