{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:51:39Z","timestamp":1791204699779,"version":"4.2.0"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Patients with type 2 diabetes mellitus (T2DM) have a higher risk of colorectal cancer (CRC), and those with diagnosed CRC have a poorer prognosis compared with individuals with normal glucose levels. The inhibition of sodium\u2010glucose cotransporter 2 (SGLT2) channels has been associated with a reduction in tumor proliferation in preclinical studies. We aimed to investigate the impact of sodium\u2010glucose cotransporter 2 inhibitors (SGLT2i) on the outcome of T2DM patients with colorectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cohort study comprising adult patients with T2DM and colorectal adenocarcinoma. SGLT2i recipients were matched to non\u2010SGLT2i recipients in a 1:1 ratio based on age, sex, and cancer stage. The primary outcome was overall survival (OS) and progression\u2010free survival (PFS), and the secondary outcomes were previously reported serious adverse events associated with SGLT2i.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 1347 patients with T2DM and colorectal adenocarcinoma, from which 92 patients in the SGLT2i cohort were matched to the non\u2010SGLT2i cohort. Compared to non\u2010SGLT2i recipients, SGLT2i recipients had a higher rate of 5\u2010year OS (86.2% [95% CI: 72.0\u201393.5]\n                      <jats:italic>vs<\/jats:italic>\n                      62.3% [95% CI: 50.9\u201371.8],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.013) and 5\u2010year PFS (76.6% [95% CI: 60.7\u201386.7]\n                      <jats:italic>vs<\/jats:italic>\n                      57.0% [95% CI: 46.2\u201366.4],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.021). In Cox proportional hazard analyses, SGLT2i were associated with a 50\u201370% reduction in all\u2010cause mortality and disease progression. SGLT2i were not associated with an increased risk of serious adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SGLT2i were associated with a higher rate of survival in T2DM patients with colorectal cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.16498","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T19:44:45Z","timestamp":1706730285000},"page":"902-907","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The impact of sodium\u2010glucose cotransporter\u20102 inhibitors on outcome of patients with diabetes mellitus and colorectal cancer"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5757-6161","authenticated-orcid":false,"given":"Cho\u2010Han","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of Medicine, Mount Auburn Hospital Harvard Medical School  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cho\u2010Hung","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan Ping","family":"Hsia","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Taipei Tzu Chi Hospital, Buddhist Tzu Chi Foundation  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aunchalee","family":"Jaroenlapnopparat","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mount Auburn Hospital Harvard Medical School  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan\u2010Sheng","family":"Horng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kit Yee","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Syuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology SUNY Downstate Medical Center  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Cheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medicine Danbury Hospital  Danbury Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian Shiian","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ze","family":"Luan","sequence":"additional","affiliation":[{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Education National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas G.","family":"Neilan","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Program, Division of Cardiology, Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Cardiovascular Imaging Research Center (CIRC), Division of Cardiology and Department of Radiology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cho\u2010Hsien","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Ming","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Da Vinci Minimally Invasive Surgery Center Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Her\u2010Shyong","family":"Shiah","sequence":"additional","affiliation":[{"name":"Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology Taipei Medical University  Taipei Taiwan"},{"name":"Department of Hematology and Oncology Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation  New Taipei City 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