{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:45:38Z","timestamp":1784033138668,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T00:00:00Z","timestamp":1708214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The rising incidence of hepatocellular carcinoma (HCC) in Australia is related to increasing rates of metabolic\u2010associated fatty liver disease (MAFLD). This study aimed to prospectively characterize the metabolic profile, lifestyle, biometric features, and response to treatment of HCC patients in an Australian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Multicenter prospective cohort analysis of newly diagnosed HCC patients at six multidisciplinary team meetings over a 2\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and thirteen (313) newly diagnosed HCC patients with MAFLD (<jats:italic>n<\/jats:italic>\u00a0=\u00a077), MAFLD plus other liver disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a057) (the \u201cmixed\u201d group), and non\u2010MAFLD (<jats:italic>n<\/jats:italic>\u00a0=\u00a0179) were included in the study. Alcohol\u2010associated liver disease (ALD) (43%) and MAFLD (43%) were the most common underlying liver diseases. MAFLD\u2010HCC patients were older (73\u00a0years <jats:italic>vs<\/jats:italic> 67\u00a0years <jats:italic>vs<\/jats:italic> 63\u00a0years), more likely to be female (40% <jats:italic>vs<\/jats:italic> 14% <jats:italic>vs<\/jats:italic> 20%), less likely to have cirrhosis (69% <jats:italic>vs<\/jats:italic> 88% <jats:italic>vs<\/jats:italic> 85%), showed higher ECOG, and were less likely to be identified by screening (29% <jats:italic>vs<\/jats:italic> 53% <jats:italic>vs<\/jats:italic> 45%). Metabolic syndrome was more prevalent in the MAFLD and mixed groups. The severity of underlying liver disease and HCC characteristics were the same across groups. While the MAFLD population self\u2010reported more sedentary lifestyles, reported dietary patterns were no different across the groups. Dyslipidemia was associated with tumor size, and those taking statins had a lower recurrence rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Equal to ALD, MAFLD is now the most common underlying liver disease seen in HCC patients in Australia. Future HCC prevention screening and treatment strategies need to take this important group of patients into consideration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16501","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T02:13:45Z","timestamp":1708308825000},"page":"1048-1056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Metabolic\u2010associated fatty liver disease and hepatocellular carcinoma: a prospective study of characteristics and response to therapy"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-3341","authenticated-orcid":false,"given":"NM","family":"Batt","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Eastern Health  Box Hill Victoria 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