{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:48:26Z","timestamp":1757310506516,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T00:00:00Z","timestamp":1708819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The study aims to develop a novel predictive model including the fibrosis (FIB)\u20103 index for hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C virus (HCV) who achieved sustained virological response (SVR) with direct\u2010acting antiviral (DAA) therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 2529 patients in whom HCV was eradicated with DAA therapy. The after DAA recommendation for surveillance (ADRES) score, which is based on sex, FIB\u20104 index, and \u03b1\u2010fetoprotein, was used to predict HCC development. We developed a modified ADRES (mADRES) score, in which the FIB\u20104 index was replaced by the FIB\u20103 index, and evaluated its usefulness in predicting HCC development compared with the ADRES score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the training set (<jats:italic>n<\/jats:italic>\u00a0=\u00a01770), multivariate analysis with Cox proportional hazards modeling showed that male sex (hazard ratio [HR], 2.11; 95% confidence interval [CI], 1.48\u20133.01), FIB\u20103 index (HR, 1.36; 95% CI, 1.28\u20131.45), and \u03b1\u2010fetoprotein (HR, 1.05; 95% CI, 1.03\u20131.07) are independently associated with HCC development. The incidence of HCC differed significantly by ADRES or mADRES score in multiple comparisons. Univariate Cox proportional hazards models showed that compared with the mADRES score 0 group, the HR for HCC development was 2.07 (95% CI, 1.02\u20134.19) for the mADRES score 1 group, 11.37 (95% CI, 5.80\u201322.27) for the mADRES score 2 group, and 21.95 (95% CI, 10.17\u201347.38) for the mADRES score 3 group. Similar results were obtained for mADRES score but not for ADRES score in the validation set (<jats:italic>n<\/jats:italic>\u00a0=\u00a0759).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The mADRES score is useful for predicting HCC development after SVR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16512","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T02:15:25Z","timestamp":1708913725000},"page":"1164-1171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["mADRES predicts hepatocellular carcinoma development in patients with hepatitis C virus who achieved sustained virological response"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-6761","authenticated-orcid":false,"given":"Toshifumi","family":"Tada","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Japanese Red Cross Society Himeji Hospital  Himeji Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-495X","authenticated-orcid":false,"given":"Takashi","family":"Kumada","sequence":"additional","affiliation":[{"name":"Department of Nursing Gifu Kyoritsu University  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-0480","authenticated-orcid":false,"given":"Atsushi","family":"Hiraoka","sequence":"additional","affiliation":[{"name":"Gastroenterology Center Ehime Prefectural Central Hospital  Matsuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3996-7502","authenticated-orcid":false,"given":"Kazuya","family":"Kariyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Okayama City Hospital  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ogaki Municipal Hospital  Ogaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fujimasa","family":"Tada","sequence":"additional","affiliation":[{"name":"Gastroenterology Center Ehime Prefectural Central Hospital  Matsuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1882-824X","authenticated-orcid":false,"given":"Hideko","family":"Ohama","sequence":"additional","affiliation":[{"name":"Gastroenterology Center Ehime Prefectural Central Hospital  Matsuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Nouso","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Okayama City Hospital  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomitsu","family":"Matono","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Himeji St. Mary's Hospital  Himeji Japan"},{"name":"Department of Gastroenterology Hyogo Prefectural Harima\u2013Himeji General Medical Center  Himeji Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Japanese Red Cross Society Himeji Hospital  Himeji Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-6168","authenticated-orcid":false,"given":"Hidenori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ogaki Municipal Hospital  Ogaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Real\u2010life Practice Experts for HCC (RELPEC) Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,25]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Health Organization (WHO).Hepatitis C.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/hepatitis\u2010c. 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